Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail

Charlotte A. Cornil, Molly J. Dickens, Gregory F. Ball, Jacques Balthazart

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Brain aromatase activity is largely controlled by steroids via modulation of the transcription of the aromatase gene that regulates the amount of available enzyme. Recent evidence, however, indicates that the kinetics of aromatase activity is also rapidly modulated by conformational changes of the protein. This discovery shifted the interest of research on aromatase towards much shorter physiological time scales and suggested that a mechanism is in place to allow changes in local estradiol concentration in a time frame compatible with the activation of fast non-genomic actions of estrogens. The present chapter provides evidence that this mechanism, discovered in vitro, is functionally significant in vivo. This chapter first reviews studies that identified rapid modulations of aromatase activity following social interactions or exposure to acute stress. Then, this chapter will focus on the implications of such rapid changes of local estrogens availability for the control of reproduction.

Original languageEnglish (US)
Title of host publicationBrain Aromatase, Estrogens, and Behavior
PublisherOxford University Press
ISBN (Print)9780199979837, 9780199841196
DOIs
StatePublished - Jan 24 2013

Fingerprint

Quail
Aromatase
Estrogens
Interpersonal Relations
Reproduction
Estradiol
Steroids
Brain
Enzymes
Research
Genes
Proteins

Keywords

  • Enzymatic activity
  • Japanese quail
  • Nongenomic effects
  • Sexual behavior
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cornil, C. A., Dickens, M. J., Ball, G. F., & Balthazart, J. (2013). Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail. In Brain Aromatase, Estrogens, and Behavior Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199841196.003.0023

Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail. / Cornil, Charlotte A.; Dickens, Molly J.; Ball, Gregory F.; Balthazart, Jacques.

Brain Aromatase, Estrogens, and Behavior. Oxford University Press, 2013.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cornil, CA, Dickens, MJ, Ball, GF & Balthazart, J 2013, Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail. in Brain Aromatase, Estrogens, and Behavior. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199841196.003.0023
Cornil CA, Dickens MJ, Ball GF, Balthazart J. Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail. In Brain Aromatase, Estrogens, and Behavior. Oxford University Press. 2013 https://doi.org/10.1093/acprof:oso/9780199841196.003.0023
Cornil, Charlotte A. ; Dickens, Molly J. ; Ball, Gregory F. ; Balthazart, Jacques. / Rapid Modulation of Aromatase Activity by Social and Environmental Stimuli in Quail. Brain Aromatase, Estrogens, and Behavior. Oxford University Press, 2013.
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