Rapid measurements of diastolic intramyocardial vascular volume

R. M. Judd, J. R. Resar, F. C.P. Yin

Research output: Contribution to journalArticlepeer-review

Abstract

Rapid measurements of coronary vascular volume are necessary for a complete understanding of phasic coronary flow. Because no standard method is capable of making these measurements, we developed a method that uses digital subtraction angiography to image an intravascular contrast agent. The method is capable of measuring vascular volume in 33 ms and can be repeated three times per second. The method was first validated in phantoms. We then used this method to measure coronary vascular volume in the isolated, perfluorochemical-perfused, interventricular canine septum. The speed of the measurements allowed us, for the first time, to directly measure transients in vascular volume following sudden changes in perfusion pressure. At the steady-state and maximal vasodilation, coronary vascular volume varied from 7.5 ± 1.2 (SE) ml/100 g at a perfusion pressure of 20 mmHg to 12.1 ± 1.9 ml/100 g at 90 mmHg, which is similar to other reports. After a sudden change of 40 mmHg in perfusion pressure, vascular volume changed with a time constant of 3.2 ± 0.3 (SE) s. Increasing ventricular wall stretch had no effect on either the steady-state volumes (P = 0.25) or the time constant for volume changes (P = 0.17). The fact that the time constant is longer than the cardiac cycle, yet much shorter than the time necessary to measure vascular volume using other methods, highlights the need for rapid measurements of vascular volume.

Original languageEnglish (US)
Pages (from-to)H1038-H1047
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume265
Issue number4 34-4
DOIs
StatePublished - 1993

Keywords

  • contrast agents
  • coronary blood volume
  • coronary capacitance
  • diastole
  • digital subtraction angiography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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