TY - JOUR
T1 - Rapid measurement of auditory filter shape in mice using the auditory brainstem response and notched noise
AU - Lina, Ioan A.
AU - Lauer, Amanda M.
N1 - Funding Information:
This research was supported by the National Organization for Hearing Research and NIH grants DC005211 and DC009353 . The funding sources had no role in the study design; data collection, analysis, and interpretation; writing of the report; or the decision to submit the manuscript for publication. We thank Eric Young and Bradford May for discussions regarding the project, and Judy Park and Jessica Stuyvenberg for data collection assistance.
PY - 2013/4
Y1 - 2013/4
N2 - The notched noise method is an effective procedure for measuring frequency resolution and auditory filter shapes in both human and animal models of hearing. Briefly, auditory filter shape and bandwidth estimates are derived from masked thresholds for tones presented in noise containing widening spectral notches. As the spectral notch widens, increasingly less of the noise falls within the auditory filter and the tone becomes more detectible until the notch width exceeds the filter bandwidth. Behavioral procedures have been used for the derivation of notched noise auditory filter shapes in mice; however, the time and effort needed to train and test animals on these tasks renders a constraint on the widespread application of this testing method. As an alternative procedure, we combined relatively non-invasive auditory brainstem response (ABR) measurements and the notched noise method to estimate auditory filters in normal-hearing mice at center frequencies of 8, 11.2, and 16 kHz. A complete set of simultaneous masked thresholds for a particular tone frequency were obtained in about an hour. ABR-derived filter bandwidths broadened with increasing frequency, consistent with previous studies. The ABR notched noise procedure provides a fast alternative to estimating frequency selectivity in mice that is well-suited to high through-put or time-sensitive screening.
AB - The notched noise method is an effective procedure for measuring frequency resolution and auditory filter shapes in both human and animal models of hearing. Briefly, auditory filter shape and bandwidth estimates are derived from masked thresholds for tones presented in noise containing widening spectral notches. As the spectral notch widens, increasingly less of the noise falls within the auditory filter and the tone becomes more detectible until the notch width exceeds the filter bandwidth. Behavioral procedures have been used for the derivation of notched noise auditory filter shapes in mice; however, the time and effort needed to train and test animals on these tasks renders a constraint on the widespread application of this testing method. As an alternative procedure, we combined relatively non-invasive auditory brainstem response (ABR) measurements and the notched noise method to estimate auditory filters in normal-hearing mice at center frequencies of 8, 11.2, and 16 kHz. A complete set of simultaneous masked thresholds for a particular tone frequency were obtained in about an hour. ABR-derived filter bandwidths broadened with increasing frequency, consistent with previous studies. The ABR notched noise procedure provides a fast alternative to estimating frequency selectivity in mice that is well-suited to high through-put or time-sensitive screening.
UR - http://www.scopus.com/inward/record.url?scp=84875810009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875810009&partnerID=8YFLogxK
U2 - 10.1016/j.heares.2013.01.002
DO - 10.1016/j.heares.2013.01.002
M3 - Article
C2 - 23347916
AN - SCOPUS:84875810009
SN - 0378-5955
VL - 298
SP - 73
EP - 79
JO - Hearing Research
JF - Hearing Research
ER -