Rapid identification of Cryptococcus neoformans and Cryptococcus gattii by matrix-assisted laser desorption ionization-time of flight mass spectrometry

Lisa R. McTaggart, Eric Lei, Susan E. Richardson, Linda Hoang, Annette Fothergill, Sean X. Zhang

Research output: Contribution to journalArticle

Abstract

Compared to DNA sequence analysis, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) correctly identified 100% of Cryptococcus species, distinguishing the notable pathogens Cryptococcus neoformans and C. gattii. Identification was greatly enhanced by supplementing a commercial spectral library with additional entries to account for subspecies variability.

Original languageEnglish (US)
Pages (from-to)3050-3053
Number of pages4
JournalJournal of clinical microbiology
Volume49
Issue number8
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Microbiology (medical)

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