Rapid diagnosis of tuberculous meningitis: What is the optimal method?

Ellen Jo Baron, Karen C. Carroll

Research output: Contribution to journalArticle

Abstract

Meningitis remains the most serious complication of infection with Mycobacterium tuberculosis. Patient recovery depends on rapid diagnosis and treatment. Findings from cerebrospinal fluid examination are nonspecific. If performed appropriately, the acid-fast bacilli smear has the same sensitivity as the currently available commercial nucleic acid amplification tests. Modifications to these commercial assays that include dilution or removal of inhibitors and concentration of organisms are encouraging but need more extensive verification on actual clinical samples. We present 2 recent cases of tuberculous meningitis and discuss currently available diagnostic methods.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalInfections in Medicine
Volume22
Issue number12
StatePublished - Dec 1 2005

Keywords

  • Culture, bacterial
  • Meningitis
  • Molecular testing
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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