Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates by heteroduplex analysis and determination of rifamycin cross-resistance in rifampin-resistant isolates

Zeynep Saribaş, Tanil Kocagöz, Alpaslan Alp, Ayfer Günalp

Research output: Contribution to journalArticlepeer-review

Abstract

Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.

Original languageEnglish (US)
Pages (from-to)816-818
Number of pages3
JournalJournal of clinical microbiology
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)

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