Rapid detection of malaria parasites

A. Feldman, J. Lin, S. Murphy, P. Demirev, David J Sullivan, P. Scholl, N. Kumar

Research output: Contribution to journalArticle

Abstract

APL and JHU Bloomberg School of Public Health researchers have demonstrated that laser desorption mass spectrometry (LDMS) was a sensitive method for detecting malaria parasites in the blood. The method is based on the detection of heme in hemozoin (Hz), the crystalline substance accumulated within malaria parasites during their intraerythrocytic growth stage. The LDMS test was performed without consumables other than a lancet and a container from blood collection. Blood was diluted in water, deposited onto a metal slide, sir dried, and inserted into the mass spectrometer for analysis. Hz heme was identified from the pattern of heme-molecular-structure-specific peaks.

Original languageEnglish (US)
Pages (from-to)232-233
Number of pages2
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Volume28
Issue number3
StatePublished - 2010

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parasites
blood
Blood
Mass spectrometry
Desorption
mass spectroscopy
desorption
APL (programming language)
public health
Lasers
Mass spectrometers
Public health
containers
chutes
Molecular structure
mass spectrometers
lasers
Containers
molecular structure
Crystalline materials

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Feldman, A., Lin, J., Murphy, S., Demirev, P., Sullivan, D. J., Scholl, P., & Kumar, N. (2010). Rapid detection of malaria parasites. Johns Hopkins APL Technical Digest (Applied Physics Laboratory), 28(3), 232-233.

Rapid detection of malaria parasites. / Feldman, A.; Lin, J.; Murphy, S.; Demirev, P.; Sullivan, David J; Scholl, P.; Kumar, N.

In: Johns Hopkins APL Technical Digest (Applied Physics Laboratory), Vol. 28, No. 3, 2010, p. 232-233.

Research output: Contribution to journalArticle

Feldman, A, Lin, J, Murphy, S, Demirev, P, Sullivan, DJ, Scholl, P & Kumar, N 2010, 'Rapid detection of malaria parasites', Johns Hopkins APL Technical Digest (Applied Physics Laboratory), vol. 28, no. 3, pp. 232-233.
Feldman A, Lin J, Murphy S, Demirev P, Sullivan DJ, Scholl P et al. Rapid detection of malaria parasites. Johns Hopkins APL Technical Digest (Applied Physics Laboratory). 2010;28(3):232-233.
Feldman, A. ; Lin, J. ; Murphy, S. ; Demirev, P. ; Sullivan, David J ; Scholl, P. ; Kumar, N. / Rapid detection of malaria parasites. In: Johns Hopkins APL Technical Digest (Applied Physics Laboratory). 2010 ; Vol. 28, No. 3. pp. 232-233.
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