Rapid detection of chinese Gγ+(Aγδβ)°-thalassemia by polymerase chain reaction

Tsang Ming Koa, Li Hιti Tseng, Fon Jou Hsieha, Sou Ming Chuang, Tzu Yao Leea

Research output: Contribution to journalArticlepeer-review

Abstract

The Chinese Gγ+(Aγδβ)°-thalassemia is caused by a deletion of more than 80 kilobases. It has a β+-thalassemia phenotype and should be differentiated from other mutations causing β-thalassemia. Using polymerase chain reaction with three oligonucleotide primers bridging the breakpoints, the deletion can be de-tected easily. The method is useful in the genetic counseling and prenatal diag-nosis of the at-risk families.

Original languageEnglish (US)
Pages (from-to)80-81
Number of pages2
JournalActa Haematologica
Volume89
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Beta-thalassemia
  • Genetic counseling
  • Polymerase chain reaction
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Hematology

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