Rapid detection of chinese Gγ+(Aγδβ)°-thalassemia by polymerase chain reaction

Tsang Ming Koa; Li Hιti Tseng; Fon Jou Hsieha; Sou Ming Chuang; Tzu Yao Leea

doi:10.1159/000204492

Rapid detection of chinese ^G^γ+(^Aγδβ)°-thalassemia by polymerase chain reaction

Tsang Ming Koa, Li Hιti Tseng, Fon Jou Hsieha, Sou Ming Chuang, Tzu Yao Leea

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The Chinese Gγ+(^Aγδβ)°-thalassemia is caused by a deletion of more than 80 kilobases. It has a β⁺-thalassemia phenotype and should be differentiated from other mutations causing β-thalassemia. Using polymerase chain reaction with three oligonucleotide primers bridging the breakpoints, the deletion can be de-tected easily. The method is useful in the genetic counseling and prenatal diag-nosis of the at-risk families.

Original language	English (US)
Pages (from-to)	80-81
Number of pages	2
Journal	Acta Haematologica
Volume	89
Issue number	2
DOIs	https://doi.org/10.1159/000204492
State	Published - 1993
Externally published	Yes

Keywords

Beta-thalassemia
Genetic counseling
Polymerase chain reaction
Prenatal diagnosis

ASJC Scopus subject areas

Hematology

Access to Document

10.1159/000204492

Cite this

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title = "Rapid detection of chinese Gγ+(Aγδβ)°-thalassemia by polymerase chain reaction",

abstract = "The Chinese Gγ+(Aγδβ)°-thalassemia is caused by a deletion of more than 80 kilobases. It has a β+-thalassemia phenotype and should be differentiated from other mutations causing β-thalassemia. Using polymerase chain reaction with three oligonucleotide primers bridging the breakpoints, the deletion can be de-tected easily. The method is useful in the genetic counseling and prenatal diag-nosis of the at-risk families.",

keywords = "Beta-thalassemia, Genetic counseling, Polymerase chain reaction, Prenatal diagnosis",

author = "Koa, {Tsang Ming} and Tseng, {Li Hιti} and Hsieha, {Fon Jou} and Chuang, {Sou Ming} and Leea, {Tzu Yao}",

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AU - Koa, Tsang Ming

AU - Tseng, Li Hιti

AU - Hsieha, Fon Jou

AU - Chuang, Sou Ming

AU - Leea, Tzu Yao

PY - 1993

Y1 - 1993

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AB - The Chinese Gγ+(Aγδβ)°-thalassemia is caused by a deletion of more than 80 kilobases. It has a β+-thalassemia phenotype and should be differentiated from other mutations causing β-thalassemia. Using polymerase chain reaction with three oligonucleotide primers bridging the breakpoints, the deletion can be de-tected easily. The method is useful in the genetic counseling and prenatal diag-nosis of the at-risk families.

KW - Beta-thalassemia

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KW - Polymerase chain reaction

KW - Prenatal diagnosis

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