Rapid control of brain aromatase activity by glutamatergic inputs

Jacques Balthazart, Michelle Baillien, Gregory F. Ball

Research output: Contribution to journalArticle

Abstract

Estrogens derived from the neural aromatization of testosterone play a key role in the activation of male sexual behavior in many vertebrates and have now been recognized to have rapid membrane effects on brain function. Such changes in aromatase activity and hence in local estrogen concentrations could rapidly modulate behavioral responses. We show here that there is a very rapid (within minutes) decrease in aromatase activity in quail hypothalamic explants exposed to treatments affecting intracellular Ca2+ concentrations, such as the addition of glutamate agonists (kainate, α-amino-3-hydroxymethyl-4- isoxazole propionic acid, and, to a much lesser extent, N-methyl-D-aspartate), but not of γ-aminobutyric acid. The kainate effects, which reduce aromatase activity by 25-50%, are observed within 5 min, are completely blocked in explants exposed to specific kainate antagonists (6-cyano-7-nitroquinoxaline- 2,3-dione disodium or 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline- 7-sulfonamide disodium), and are also rapidly reversible when effectors are washed out. Together, these data support the idea that the synthesis of estrogen can be rapidly regulated in the brain, thus producing rapid changes in local estrogen bioavailability that could rapidly modify brain function with a time course similar to what has previously been described for neurotransmitters and neuromodulators.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalEndocrinology
Volume147
Issue number1
DOIs
StatePublished - Jan 2006

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Aromatase
Kainic Acid
Estrogens
Brain
Neurotransmitter Agents
6-Cyano-7-nitroquinoxaline-2,3-dione
Aminobutyrates
Isoxazoles
Excitatory Amino Acid Agonists
Quail
Sulfonamides
N-Methylaspartate
Sexual Behavior
Biological Availability
Vertebrates
Testosterone
Membranes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rapid control of brain aromatase activity by glutamatergic inputs. / Balthazart, Jacques; Baillien, Michelle; Ball, Gregory F.

In: Endocrinology, Vol. 147, No. 1, 01.2006, p. 359-366.

Research output: Contribution to journalArticle

Balthazart, J, Baillien, M & Ball, GF 2006, 'Rapid control of brain aromatase activity by glutamatergic inputs', Endocrinology, vol. 147, no. 1, pp. 359-366. https://doi.org/10.1210/en.2005-0845
Balthazart, Jacques ; Baillien, Michelle ; Ball, Gregory F. / Rapid control of brain aromatase activity by glutamatergic inputs. In: Endocrinology. 2006 ; Vol. 147, No. 1. pp. 359-366.
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