Rapid antiretroviral therapy initiation for women in an HIV-1 prevention clinical trial experiencing primary HIV-1 infection during pregnancy or breastfeeding

Susan Morrison, Grace John-Stewart, John J. Egessa, Sezi Mubezi, Sylvia Kusemererwa, Dennis K. Bii, Nulu Bulya, Francis Mugume, James D. Campbell, Jonathan Wangisi, Elizabeth A. Bukusi, Connie Celum, Jared M. Baeten, Deborah Donnell, Robert W. Coombs, Lisa Frenkel, Craig W. Hendrix, Jairam Lingappa, M. Juliana McElrath

Research output: Contribution to journalArticlepeer-review

Abstract

During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primaryHIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancyand breastfeeding is feasible in this setting.

Original languageEnglish (US)
Article numbere0140773
JournalPloS one
Volume10
Issue number10
DOIs
StatePublished - Oct 15 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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