RAP80, ubiquitin and SUMO in the DNA damage response

Research output: Contribution to journalReview articlepeer-review

Abstract

A decade has passed since the first reported connection between RAP80 and BRCA1 in DNA double-strand break repair. Despite the initial identification of RAP80 as a factor localizing BRCA1 to DNA double-strand breaks and potentially promoting homologous recombination, there is increasing evidence that RAP80 instead suppresses homologous recombination to fine-tune the balance of competing DNA repair processes during the S/G2 phase of the cell cycle. RAP80 opposes homologous recombination by inhibiting DNA end-resection and sequestering BRCA1 into the BRCA1-A complex. Ubiquitin and SUMO modifications of chromatin at DNA double-strand breaks recruit RAP80, which contains distinct sequence motifs that recognize ubiquitin and SUMO. Here, we review RAP80’s role in repressing homologous recombination at DNA double-strand breaks and how this role is facilitated by its ability to bind ubiquitin and SUMO modifications.

Original languageEnglish (US)
Pages (from-to)799-807
Number of pages9
JournalJournal of Molecular Medicine
Volume95
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • BRCA1
  • DNA double-strand break repair
  • Homologous recombination
  • RAP80
  • SUMO
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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