TY - GEN
T1 - Randomness in resting state functional connectivity matrices
AU - Vergara, Victor M.
AU - Calhoun, Vince
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Separate brain regions exhibit synchronous intrinsic activity used to assess connectivity patterns known to appear among brain areas. Connectivity is evaluated from functional magnetic resonance imaging (fMRI) measuring the blood oxygen level dependent signal (BOLD) signal. Extensive research has revealed a distinctive pattern of connectivity among brain areas that can be visualized through a functional connectivity matrix (FCM) matrix. As in any measurement, BOLD signals are subject to contamination from noise and nuisances unrelated to brain's intrinsic activity. Up until now, little work has been developed to determine if patterns observed in FCMs occurred by chance or were driven by a more deterministic process. This work proposes a mathematical framework to test the randomness of FCM connectivity patterns in a systematic and statistical way. A cohort of 121 healthy controls is used to demonstrate the usefulness of the proposed framework. Results indicate that particular parts of the brain might exhibit decreasing randomness with age and gender. Results also show the framework's effectiveness in assessing FCM randomness.
AB - Separate brain regions exhibit synchronous intrinsic activity used to assess connectivity patterns known to appear among brain areas. Connectivity is evaluated from functional magnetic resonance imaging (fMRI) measuring the blood oxygen level dependent signal (BOLD) signal. Extensive research has revealed a distinctive pattern of connectivity among brain areas that can be visualized through a functional connectivity matrix (FCM) matrix. As in any measurement, BOLD signals are subject to contamination from noise and nuisances unrelated to brain's intrinsic activity. Up until now, little work has been developed to determine if patterns observed in FCMs occurred by chance or were driven by a more deterministic process. This work proposes a mathematical framework to test the randomness of FCM connectivity patterns in a systematic and statistical way. A cohort of 121 healthy controls is used to demonstrate the usefulness of the proposed framework. Results indicate that particular parts of the brain might exhibit decreasing randomness with age and gender. Results also show the framework's effectiveness in assessing FCM randomness.
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U2 - 10.1109/EMBC.2016.7591987
DO - 10.1109/EMBC.2016.7591987
M3 - Conference contribution
C2 - 28269516
AN - SCOPUS:85009083822
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5563
EP - 5566
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Y2 - 16 August 2016 through 20 August 2016
ER -