Randomized trials of induction chemotherapy: A critical review

Research output: Contribution to journalArticle

Abstract

The incorporation of chemotherapy into a combined modality approach for treating newly diagnosed, advanced head and neck cancer has been under evaluation since the 1970s. In this review, the criteria for a well-designed prospective randomized trial are delineated based on prognostic factors determined from single-institution induction chemotherapy trials. The results of randomized controlled trials conducted from 1978 to the present are discussed with respect to their impact on survival, locoregional disease control, and the development of distant metastasis. Each study is then critiqued for its design, conduct, and interpretation. Organ preservation, improved locoregional control, and survival are important goals for future trials.

Original languageEnglish (US)
Pages (from-to)725-736
Number of pages12
JournalHematology/Oncology Clinics of North America
Volume5
Issue number4
StatePublished - 1991

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Organ Preservation
Induction Chemotherapy
Head and Neck Neoplasms
Randomized Controlled Trials
Neoplasm Metastasis
Drug Therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Randomized trials of induction chemotherapy : A critical review. / Forastiere, Arlene A.

In: Hematology/Oncology Clinics of North America, Vol. 5, No. 4, 1991, p. 725-736.

Research output: Contribution to journalArticle

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