TY - JOUR
T1 - Randomized trials of induction chemotherapy
T2 - A critical review
AU - Forastiere, A. A.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - The incorporation of chemotherapy into a combined modality approach for treating newly diagnosed, advanced head and neck cancer has been under evaluation since the 1970s. In this review, the criteria for a well-designed prospective randomized trial are delineated based on prognostic factors determined from single-institution induction chemotherapy trials. The results of randomized controlled trials conducted from 1978 to the present are discussed with respect to their impact on survival, locoregional disease control, and the development of distant metastasis. Each study is then critiqued for its design, conduct, and interpretation. Organ preservation, improved locoregional control, and survival are important goals for future trials.
AB - The incorporation of chemotherapy into a combined modality approach for treating newly diagnosed, advanced head and neck cancer has been under evaluation since the 1970s. In this review, the criteria for a well-designed prospective randomized trial are delineated based on prognostic factors determined from single-institution induction chemotherapy trials. The results of randomized controlled trials conducted from 1978 to the present are discussed with respect to their impact on survival, locoregional disease control, and the development of distant metastasis. Each study is then critiqued for its design, conduct, and interpretation. Organ preservation, improved locoregional control, and survival are important goals for future trials.
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U2 - 10.1016/s0889-8588(18)30412-x
DO - 10.1016/s0889-8588(18)30412-x
M3 - Review article
C2 - 1890063
AN - SCOPUS:0025862206
SN - 0889-8588
VL - 5
SP - 725
EP - 736
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 4
ER -