Randomized trial to compare the effect of recombinant human FSH (follitropian alfa) with or without recombinant human LH in women udergoing assisted reproduction treatment

Richard Marrs, D. Meldrum, S. Muasher, W. Schoolcraft, L. Werlin, Eduardo Kelly

Research output: Contribution to journalArticle

Abstract

Women undergoing intracytoplasmic sperm injection (ICSI) for male factor infertility were randomly assigned to receive ovarian stimulation in a long agonist protocol with a combination of recombinant human FSH (r-hFSH; Gonal-F®) and recombinant human LH (r-hLH; Luveris®) (n = 212) stating on day 6 of FSH stimulation until human chorionic gonadotrophin (HCG) at a daily fixed dose of 150 IU r-hLH, or with r-hFSH alone (n = 219). There was no significant difference in the number of metaphase II oocytes retrieved (10.3 versus 10.4) in patients treated with r-hFSH and r-hLH versus r-hFSH alone; however, more embryos were transferred in the LH-supplemented group (2.9 versus 2.8, P = 0.037). Overall, the implantation rates were 22.9 versus 27.0% in patients treated with r-hFSH and r-hLH versus with r-hFSH alone respectively (NS). The respective numbers of MII oocytes retrieved in patients <35 or ≥35 years were 11 versus 8.3 (P = 0.010) for patients treated with r-hFSH alone, and 10.7 versus 9.3 (NS) for those given supplemental r-hLH (150 IU) from day 6. Implantation rates in patients <35 years treated with r-hFSH were higher (30.7%) than those receiving r-hFSH and r-hLH, (23.5%) (P = 0.068). In patients ≥35 years, the implantation rates were 21.7% for those patients supplemented with 150 IU r-hLH from day 6 of stimulation versus 15.7% when treated with FSH alone (NS). Younger patients therefore do not seem to benefit from an LH-supplemented ovarian stimulation protocol, but women ≥35 years undergoing assisted reproduction may benefit from using r-hLH in addition to r-hFSH.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalReproductive biomedicine online
Volume8
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Age
  • Ovarian stimulation
  • Recombinant FSH
  • Recombinant LH

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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