Randomized trial of salbutamol in acute bronchiolitis

Terry P. Klassen, Peter Rowe, Terry Sutcliffe, Leland J. Ropp, W. McDowell, Marllyn M. Li

Research output: Contribution to journalArticle

Abstract

To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p=0.04). There was no difference between the groups in oxygen saturation (p=0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159±16 vs 151±16; p=0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.

Original languageEnglish (US)
Pages (from-to)807-811
Number of pages5
JournalJournal of Pediatrics
Volume118
Issue number5
DOIs
StatePublished - 1991
Externally publishedYes

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Bronchiolitis
Albuterol
Sodium Chloride
Therapeutics
Oximetry
Respiratory Sounds
Respiratory Rate
Heart Rate
Placebos
Outcome Assessment (Health Care)
Clinical Trials
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Klassen, T. P., Rowe, P., Sutcliffe, T., Ropp, L. J., McDowell, W., & Li, M. M. (1991). Randomized trial of salbutamol in acute bronchiolitis. Journal of Pediatrics, 118(5), 807-811. https://doi.org/10.1016/S0022-3476(05)80051-4

Randomized trial of salbutamol in acute bronchiolitis. / Klassen, Terry P.; Rowe, Peter; Sutcliffe, Terry; Ropp, Leland J.; McDowell, W.; Li, Marllyn M.

In: Journal of Pediatrics, Vol. 118, No. 5, 1991, p. 807-811.

Research output: Contribution to journalArticle

Klassen, TP, Rowe, P, Sutcliffe, T, Ropp, LJ, McDowell, W & Li, MM 1991, 'Randomized trial of salbutamol in acute bronchiolitis', Journal of Pediatrics, vol. 118, no. 5, pp. 807-811. https://doi.org/10.1016/S0022-3476(05)80051-4
Klassen, Terry P. ; Rowe, Peter ; Sutcliffe, Terry ; Ropp, Leland J. ; McDowell, W. ; Li, Marllyn M. / Randomized trial of salbutamol in acute bronchiolitis. In: Journal of Pediatrics. 1991 ; Vol. 118, No. 5. pp. 807-811.
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