Abstract
To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p=0.04). There was no difference between the groups in oxygen saturation (p=0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159±16 vs 151±16; p=0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 807-811 |
| Number of pages | 5 |
| Journal | Journal of Pediatrics |
| Volume | 118 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Randomized trial of salbutamol in acute bronchiolitis. / Klassen, Terry P.; Rowe, Peter; Sutcliffe, Terry; Ropp, Leland J.; McDowell, W.; Li, Marllyn M.
In: Journal of Pediatrics, Vol. 118, No. 5, 1991, p. 807-811.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Randomized trial of salbutamol in acute bronchiolitis
AU - Klassen, Terry P.
AU - Rowe, Peter
AU - Sutcliffe, Terry
AU - Ropp, Leland J.
AU - McDowell, W.
AU - Li, Marllyn M.
PY - 1991
Y1 - 1991
N2 - To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p=0.04). There was no difference between the groups in oxygen saturation (p=0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159±16 vs 151±16; p=0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.
AB - To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p=0.04). There was no difference between the groups in oxygen saturation (p=0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159±16 vs 151±16; p=0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.
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U2 - 10.1016/S0022-3476(05)80051-4
DO - 10.1016/S0022-3476(05)80051-4
M3 - Article
C2 - 2019938
AN - SCOPUS:0025876234
VL - 118
SP - 807
EP - 811
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -