Randomized pilot study comparing rates of endocervical cell recovery between conventional pap smears and liquid-based cytology in a pregnant population

Janine Kruger, Charles J. Dunton, Catherine Sewell, Elyce Cardonick

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To determine whether liquid-based cytology improves Pap smear adequacy, as defined by the presence of endocervical cells, compared with conventional cytology during pregnancy. Materials and methods. A randomized pilot study was conducted between May 2001 and May 2002. Patients presenting for their first prenatal visit were randomized to receive either a conventional Pap smear or a liquid-based smear (ThinPrep). Rates of endocervical cell recovery and cytologic results were compared between the groups. Results. Eighty-one patients were enrolled in the study. There were no differences between the groups in age (p = .40), parity (p = .62), gestational age (p = .14), history of abnormal pap (p = .08), previous treatment of neoplasia (p = 1.00), and tobacco use (p = .67). Adequacy of the standard pap versus the liquid-based smear was not different between the two groups (90.5% vs 82.1%, respectively; p = .34). Conclusions. The results of this pilot study show that rates of endocervical cell recovery in a pregnant population are not statistically different using conventional or liquid-based cytology. Further research is indicated to assess the utility of the more expensive ThinPrep-technology in this population.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalJournal of lower genital tract disease
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2003

Keywords

  • Adequacy
  • Cervical intraepithelial neoplasia
  • Pap smear
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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