TY - JOUR
T1 - Randomized controlled trial of hospital-based hygiene and water treatment intervention (CHoBI7) to reduce cholera
AU - George, Christine Marie
AU - Monira, Shirajum
AU - Sack, David A.
AU - Rashid, Mahamud Ur
AU - Saif-Ur-Rahman, K. M.
AU - Mahmud, Toslim
AU - Rahman, Zillur
AU - Mustafiz, Munshi
AU - Bhuyian, Sazzadul Islam
AU - Winch, Peter J.
AU - Leontsini, Elli
AU - Perin, Jamie
AU - Begum, Farzana
AU - Zohura, Fatema
AU - Biswas, Shwapon
AU - Parvin, Tahmina
AU - Zhang, Xiaotong
AU - Jung, Danielle
AU - Sack, R. Bradley
AU - Alam, Munirul
N1 - Publisher Copyright:
© 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013-2014. Intervention contacts had signifi- cantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.
AB - The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013-2014. Intervention contacts had signifi- cantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.
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U2 - 10.3201/eid2202.151175
DO - 10.3201/eid2202.151175
M3 - Article
C2 - 26811968
AN - SCOPUS:84955093086
SN - 1080-6040
VL - 22
SP - 233
EP - 241
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 2
ER -