Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well being

Judith Bass, Robert Opoka, Itziar Familiar, Noeline Nakasujja, Alla Sikorskii, Jorem Awadu, Deborah Givon, Cilly Shohet, Sarah Murray, Jura Augustinavicius, Tamar Mendelson, Michael Boivin

Research output: Contribution to journalArticle

Abstract

Objectives: HIV infection places children at neurodevelopmental risk; for young children in poverty, risk is compounded by compromised caregiving quality. The mediational intervention for sensitizing caregivers (MISC) program trained caregivers on fostering daily interactions with young children. We hypothesized that MISC could enhance neurodevelopment of rural Ugandan HIV-infected children and improve mental health outcomes of their caregivers, which might mediate improved caregiving quality. Design: A randomized trial of HIV-infected young children (ages 2-5 years) and their female caregivers; cluster randomization was to MISC or a nutrition curriculum. Setting: A total of 18 geographic clusters in rural Uganda. Study participants: Children and caregivers were evaluated at baseline, 6 months, 1 year, and 1-year post-training. Main outcome measures: Mullen Scales of Early Learning, the Color-Object Association Test for memory, the Early Childhood Vigilance Test of attention, and the Behavior Rating Inventory of Executive Function for the children. Caregivers completed measures of depression and anxiety symptoms and daily functioning. Results: MISC had a significant impact on postintervention receptive language (adjusted mean difference = 3.13, 95% confidence interval 0.08, 6.18) that persisted at 1-year follow-up. MISC caregivers reported significantly less functional impairment postprogram (adjusted mean difference = -0.15, 95% confidence interval -0.28, -0.01). Other outcomes were NS. Conclusion: Both intervention conditions resulted in improvements in the study children over time. MISC showed additional impacts on child language and caregiver well-being. Future directions that include assessing the extent enhanced language development resulting from improved caregiving may better prepare impoverished children for school.

Original languageEnglish (US)
Pages (from-to)1877-1883
Number of pages7
JournalAIDS
Volume31
Issue number13
DOIs
StatePublished - Aug 24 2017

Fingerprint

Caregivers
Randomized Controlled Trials
HIV
Confidence Intervals
Child Language
Language Development
Foster Home Care
Uganda
Executive Function
Poverty
Random Allocation
Curriculum
HIV Infections
Mental Health
Language
Anxiety
Color
Outcome Assessment (Health Care)
Learning
Depression

Keywords

  • caregiver intervention
  • child development
  • HIV-infected children
  • lower and middle income countries
  • psychosocial

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Bass, J., Opoka, R., Familiar, I., Nakasujja, N., Sikorskii, A., Awadu, J., ... Boivin, M. (2017). Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well being. AIDS, 31(13), 1877-1883. https://doi.org/10.1097/QAD.0000000000001563

Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well being. / Bass, Judith; Opoka, Robert; Familiar, Itziar; Nakasujja, Noeline; Sikorskii, Alla; Awadu, Jorem; Givon, Deborah; Shohet, Cilly; Murray, Sarah; Augustinavicius, Jura; Mendelson, Tamar; Boivin, Michael.

In: AIDS, Vol. 31, No. 13, 24.08.2017, p. 1877-1883.

Research output: Contribution to journalArticle

Bass, Judith ; Opoka, Robert ; Familiar, Itziar ; Nakasujja, Noeline ; Sikorskii, Alla ; Awadu, Jorem ; Givon, Deborah ; Shohet, Cilly ; Murray, Sarah ; Augustinavicius, Jura ; Mendelson, Tamar ; Boivin, Michael. / Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well being. In: AIDS. 2017 ; Vol. 31, No. 13. pp. 1877-1883.
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