Randomized comparison of diode laser photocoagulation versus cryotherapy for threshold retinopathy of prematurity

Three year outcome

Michael X Repka, J. E. White

Research output: Contribution to journalArticle

Abstract

Purpose: To report the structural and functional outcomes at 3 years postmenstrual age for the treatment of threshold retinopathy of prematurity. Methods: Nineteen patients were entered into a prospective randomized treatment protocol, in which one eye received cryotherapy and one eye received diode laser photocoagulation. Asymmetric eyes were randomly assigned. Two patients have died and and 3 patients are no longer available for 3 year outcome exams. Results: Eight males and 5 females participated with a mean birthweight of 655 grams and a mean gestational age of 24.8 weeks. Four patients had asymmetrical disease, 3 receiving laser photocoagulation and one cryotherapy. Thirteen patients were able to have acuity determined. Seven patients (50%) have developed strabismus. There were 2 discordant outcomes, with the laser eye having the favorable outcome. Laser photocoagulation Cryotherapy P value Number of eyes treated 13 11 Geometric Mean Visual Acuity 20/46 20/72 0.05 Mean refractive error -5.97 D -7.06 D NS Favorable structural outcome 13/13 9/11 NS. Conclusions: Laser photocoagulation appears to have an outcome comparable to cryotherapy when the patients are examined three years following therapy. These data are suggestive that laser photocoagulation may have a minimal advantage.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996

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Semiconductor Lasers
Retinopathy of Prematurity
Cryotherapy
Light Coagulation
Lasers
Refractive Errors
Strabismus
Clinical Protocols
Gestational Age
Visual Acuity
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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abstract = "Purpose: To report the structural and functional outcomes at 3 years postmenstrual age for the treatment of threshold retinopathy of prematurity. Methods: Nineteen patients were entered into a prospective randomized treatment protocol, in which one eye received cryotherapy and one eye received diode laser photocoagulation. Asymmetric eyes were randomly assigned. Two patients have died and and 3 patients are no longer available for 3 year outcome exams. Results: Eight males and 5 females participated with a mean birthweight of 655 grams and a mean gestational age of 24.8 weeks. Four patients had asymmetrical disease, 3 receiving laser photocoagulation and one cryotherapy. Thirteen patients were able to have acuity determined. Seven patients (50{\%}) have developed strabismus. There were 2 discordant outcomes, with the laser eye having the favorable outcome. Laser photocoagulation Cryotherapy P value Number of eyes treated 13 11 Geometric Mean Visual Acuity 20/46 20/72 0.05 Mean refractive error -5.97 D -7.06 D NS Favorable structural outcome 13/13 9/11 NS. Conclusions: Laser photocoagulation appears to have an outcome comparable to cryotherapy when the patients are examined three years following therapy. These data are suggestive that laser photocoagulation may have a minimal advantage.",
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