TY - JOUR
T1 - Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru
AU - Penny, M. E.
AU - Peerson, J. M.
AU - Marin, R. M.
AU - Duran, A.
AU - Lanata, C. F.
AU - Lonnerdal, B.
AU - Black, R. E.
AU - Brown, K. H.
N1 - Funding Information:
Supported by The Thrasher Research Fund and the World Health Organization.
PY - 1999
Y1 - 1999
N2 - Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95% (group P), 94% (group Z); or 88% (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28% in children in group Z (P = .01) and by 33% in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.
AB - Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95% (group P), 94% (group Z); or 88% (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28% in children in group Z (P = .01) and by 33% in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.
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U2 - 10.1016/S0022-3476(99)70024-7
DO - 10.1016/S0022-3476(99)70024-7
M3 - Article
C2 - 10431116
AN - SCOPUS:0033509870
SN - 0022-3476
VL - 135
SP - 208
EP - 217
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2 I
ER -