Randomization: Beyond the closurization principle

Lawrence H. Moulton

doi:10.1177/17407745221080714

Randomization: Beyond the closurization principle

Lawrence H. Moulton

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Many cluster randomized trials have relatively few numbers of clusters to be randomized. When baseline cluster-level covariates are available prior to randomization, the set of potential allocations can be restricted so as to ensure balance across study arms. This article discusses why and how restrictions can be made, and the ramifications of so doing. The Fisher–Bailey validity is explained, and examples are given regarding the tradeoff between balance and validity.

Original language	English (US)
Pages (from-to)	396-401
Number of pages	6
Journal	Clinical Trials
Volume	19
Issue number	4
DOIs	https://doi.org/10.1177/17407745221080714
State	Published - Aug 2022

Keywords

Cluster randomized trial
randomization
study design

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1177/17407745221080714

Cite this

@article{8bb25f5edf254952b41059f81dda24d7,

title = "Randomization: Beyond the closurization principle",

abstract = "Many cluster randomized trials have relatively few numbers of clusters to be randomized. When baseline cluster-level covariates are available prior to randomization, the set of potential allocations can be restricted so as to ensure balance across study arms. This article discusses why and how restrictions can be made, and the ramifications of so doing. The Fisher–Bailey validity is explained, and examples are given regarding the tradeoff between balance and validity.",

keywords = "Cluster randomized trial, randomization, study design",

author = "Moulton, {Lawrence H.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = aug,

doi = "10.1177/17407745221080714",

language = "English (US)",

volume = "19",

pages = "396--401",

journal = "Clinical Trials",

issn = "1740-7745",

publisher = "SAGE Publications Ltd",

number = "4",

}

TY - JOUR

T1 - Randomization

T2 - Beyond the closurization principle

AU - Moulton, Lawrence H.

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/8

Y1 - 2022/8

N2 - Many cluster randomized trials have relatively few numbers of clusters to be randomized. When baseline cluster-level covariates are available prior to randomization, the set of potential allocations can be restricted so as to ensure balance across study arms. This article discusses why and how restrictions can be made, and the ramifications of so doing. The Fisher–Bailey validity is explained, and examples are given regarding the tradeoff between balance and validity.

AB - Many cluster randomized trials have relatively few numbers of clusters to be randomized. When baseline cluster-level covariates are available prior to randomization, the set of potential allocations can be restricted so as to ensure balance across study arms. This article discusses why and how restrictions can be made, and the ramifications of so doing. The Fisher–Bailey validity is explained, and examples are given regarding the tradeoff between balance and validity.

KW - Cluster randomized trial

KW - randomization

KW - study design

UR - http://www.scopus.com/inward/record.url?scp=85125727947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85125727947&partnerID=8YFLogxK

U2 - 10.1177/17407745221080714

DO - 10.1177/17407745221080714

M3 - Article

C2 - 35232309

AN - SCOPUS:85125727947

SN - 1740-7745

VL - 19

SP - 396

EP - 401

JO - Clinical Trials

JF - Clinical Trials

IS - 4

ER -

Randomization: Beyond the closurization principle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this