Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population

Frederik Cold, Kristian H. Winther, Roberto Pastor-Barriuso, Margaret P. Rayman, Eliseo Guallar, Mads Nybo, Bruce A. Griffin, Saverio Stranges, Soren Cold

Research output: Contribution to journalArticle

Abstract

Although cross-sectional studies have shown a positive association between Se and cholesterol concentrations, a recent randomised controlled trial in 501 elderly UK individuals of relatively low-Se status found that Se supplementation for 6 months lowered total plasma cholesterol. The Danish PRECISE (PREvention of Cancer by Intervention with Selenium) pilot study (ClinicalTrials.gov ID: NCT01819649) was a 5-year randomised, double-blinded, placebo-controlled trial with four groups (allocation ratio 1:1:1:1). Men and women aged 60-74 years (n 491) were randomised to 100 (n 124), 200 (n 122) or 300 (n 119) μg Se-enriched yeast or matching placebo-yeast tablets (n 126) daily for 5 years. A total of 468 participants continued the study for 6 months and 361 participants, equally distributed across treatment groups, continued for 5 years. Plasma samples were analysed for total and HDL-cholesterol and for total Se concentrations at baseline, 6 months and 5 years. The effect of different doses of Se supplementation on plasma lipid and Se concentrations was estimated by using linear mixed models. Plasma Se concentration increased significantly and dose-dependently in the intervention groups after 6 months and 5 years. Total cholesterol decreased significantly both in the intervention groups and in the placebo group after 6 months and 5 years, with small and nonsignificant differences in changes in plasma concentration of total cholesterol, HDL-cholesterol, non-HDL-cholesterol and total:HDL-cholesterol ratio between intervention and placebo groups. The effect of long-term supplementation with Se on plasma cholesterol concentrations or its sub-fractions did not differ significantly from placebo in this elderly population.

Original languageEnglish (US)
Pages (from-to)1807-1818
Number of pages12
JournalBritish Journal of Nutrition
Volume114
Issue number11
DOIs
StatePublished - Sep 22 2015

Fingerprint

Selenium
Randomized Controlled Trials
Cholesterol
Placebos
HDL Cholesterol
Population
Yeasts
Tablets
Linear Models
Cross-Sectional Studies
Lipids
Neoplasms

Keywords

  • Cholesterol
  • CVD
  • Lipids
  • Randomised controlled trials
  • Selenium
  • Selenium supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population. / Cold, Frederik; Winther, Kristian H.; Pastor-Barriuso, Roberto; Rayman, Margaret P.; Guallar, Eliseo; Nybo, Mads; Griffin, Bruce A.; Stranges, Saverio; Cold, Soren.

In: British Journal of Nutrition, Vol. 114, No. 11, 22.09.2015, p. 1807-1818.

Research output: Contribution to journalArticle

Cold, F, Winther, KH, Pastor-Barriuso, R, Rayman, MP, Guallar, E, Nybo, M, Griffin, BA, Stranges, S & Cold, S 2015, 'Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population', British Journal of Nutrition, vol. 114, no. 11, pp. 1807-1818. https://doi.org/10.1017/S0007114515003499
Cold, Frederik ; Winther, Kristian H. ; Pastor-Barriuso, Roberto ; Rayman, Margaret P. ; Guallar, Eliseo ; Nybo, Mads ; Griffin, Bruce A. ; Stranges, Saverio ; Cold, Soren. / Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population. In: British Journal of Nutrition. 2015 ; Vol. 114, No. 11. pp. 1807-1818.
@article{2bec84f6e9b946ae818a6653e0a76a55,
title = "Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population",
abstract = "Although cross-sectional studies have shown a positive association between Se and cholesterol concentrations, a recent randomised controlled trial in 501 elderly UK individuals of relatively low-Se status found that Se supplementation for 6 months lowered total plasma cholesterol. The Danish PRECISE (PREvention of Cancer by Intervention with Selenium) pilot study (ClinicalTrials.gov ID: NCT01819649) was a 5-year randomised, double-blinded, placebo-controlled trial with four groups (allocation ratio 1:1:1:1). Men and women aged 60-74 years (n 491) were randomised to 100 (n 124), 200 (n 122) or 300 (n 119) μg Se-enriched yeast or matching placebo-yeast tablets (n 126) daily for 5 years. A total of 468 participants continued the study for 6 months and 361 participants, equally distributed across treatment groups, continued for 5 years. Plasma samples were analysed for total and HDL-cholesterol and for total Se concentrations at baseline, 6 months and 5 years. The effect of different doses of Se supplementation on plasma lipid and Se concentrations was estimated by using linear mixed models. Plasma Se concentration increased significantly and dose-dependently in the intervention groups after 6 months and 5 years. Total cholesterol decreased significantly both in the intervention groups and in the placebo group after 6 months and 5 years, with small and nonsignificant differences in changes in plasma concentration of total cholesterol, HDL-cholesterol, non-HDL-cholesterol and total:HDL-cholesterol ratio between intervention and placebo groups. The effect of long-term supplementation with Se on plasma cholesterol concentrations or its sub-fractions did not differ significantly from placebo in this elderly population.",
keywords = "Cholesterol, CVD, Lipids, Randomised controlled trials, Selenium, Selenium supplementation",
author = "Frederik Cold and Winther, {Kristian H.} and Roberto Pastor-Barriuso and Rayman, {Margaret P.} and Eliseo Guallar and Mads Nybo and Griffin, {Bruce A.} and Saverio Stranges and Soren Cold",
year = "2015",
month = "9",
day = "22",
doi = "10.1017/S0007114515003499",
language = "English (US)",
volume = "114",
pages = "1807--1818",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "11",

}

TY - JOUR

T1 - Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population

AU - Cold, Frederik

AU - Winther, Kristian H.

AU - Pastor-Barriuso, Roberto

AU - Rayman, Margaret P.

AU - Guallar, Eliseo

AU - Nybo, Mads

AU - Griffin, Bruce A.

AU - Stranges, Saverio

AU - Cold, Soren

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Although cross-sectional studies have shown a positive association between Se and cholesterol concentrations, a recent randomised controlled trial in 501 elderly UK individuals of relatively low-Se status found that Se supplementation for 6 months lowered total plasma cholesterol. The Danish PRECISE (PREvention of Cancer by Intervention with Selenium) pilot study (ClinicalTrials.gov ID: NCT01819649) was a 5-year randomised, double-blinded, placebo-controlled trial with four groups (allocation ratio 1:1:1:1). Men and women aged 60-74 years (n 491) were randomised to 100 (n 124), 200 (n 122) or 300 (n 119) μg Se-enriched yeast or matching placebo-yeast tablets (n 126) daily for 5 years. A total of 468 participants continued the study for 6 months and 361 participants, equally distributed across treatment groups, continued for 5 years. Plasma samples were analysed for total and HDL-cholesterol and for total Se concentrations at baseline, 6 months and 5 years. The effect of different doses of Se supplementation on plasma lipid and Se concentrations was estimated by using linear mixed models. Plasma Se concentration increased significantly and dose-dependently in the intervention groups after 6 months and 5 years. Total cholesterol decreased significantly both in the intervention groups and in the placebo group after 6 months and 5 years, with small and nonsignificant differences in changes in plasma concentration of total cholesterol, HDL-cholesterol, non-HDL-cholesterol and total:HDL-cholesterol ratio between intervention and placebo groups. The effect of long-term supplementation with Se on plasma cholesterol concentrations or its sub-fractions did not differ significantly from placebo in this elderly population.

AB - Although cross-sectional studies have shown a positive association between Se and cholesterol concentrations, a recent randomised controlled trial in 501 elderly UK individuals of relatively low-Se status found that Se supplementation for 6 months lowered total plasma cholesterol. The Danish PRECISE (PREvention of Cancer by Intervention with Selenium) pilot study (ClinicalTrials.gov ID: NCT01819649) was a 5-year randomised, double-blinded, placebo-controlled trial with four groups (allocation ratio 1:1:1:1). Men and women aged 60-74 years (n 491) were randomised to 100 (n 124), 200 (n 122) or 300 (n 119) μg Se-enriched yeast or matching placebo-yeast tablets (n 126) daily for 5 years. A total of 468 participants continued the study for 6 months and 361 participants, equally distributed across treatment groups, continued for 5 years. Plasma samples were analysed for total and HDL-cholesterol and for total Se concentrations at baseline, 6 months and 5 years. The effect of different doses of Se supplementation on plasma lipid and Se concentrations was estimated by using linear mixed models. Plasma Se concentration increased significantly and dose-dependently in the intervention groups after 6 months and 5 years. Total cholesterol decreased significantly both in the intervention groups and in the placebo group after 6 months and 5 years, with small and nonsignificant differences in changes in plasma concentration of total cholesterol, HDL-cholesterol, non-HDL-cholesterol and total:HDL-cholesterol ratio between intervention and placebo groups. The effect of long-term supplementation with Se on plasma cholesterol concentrations or its sub-fractions did not differ significantly from placebo in this elderly population.

KW - Cholesterol

KW - CVD

KW - Lipids

KW - Randomised controlled trials

KW - Selenium

KW - Selenium supplementation

UR - http://www.scopus.com/inward/record.url?scp=84949318900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949318900&partnerID=8YFLogxK

U2 - 10.1017/S0007114515003499

DO - 10.1017/S0007114515003499

M3 - Article

VL - 114

SP - 1807

EP - 1818

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 11

ER -