TY - JOUR
T1 - Rainer Gross Award Lecture 2018
T2 - The Childhood Plasma Proteome: Discovering its Applications in Public Health Nutrition
AU - Lee, Sun Eun
AU - Schulze, Kerry
AU - West, Keith P.
N1 - Funding Information:
The authors are grateful to core members of the Johns Hopkins Nutriproteomics Research Team, including Parul Christian, Robert Cole, Lauren DeVine, John Groopman, Shelly Herbrich, Bareng AS Nonyane, Robert O’Meally, Ingo Ruczinski, Lee Shu-Fune Wu and James Yager. The authors thank the Bill & Melinda Gates Foundation for its support of the original antenatal micronutrient trial and the 7-year postpartum follow-up study (GH614, Ellen Piwoz), and the nutriproteomics research reported here (OPP5241, Yiwu He). Our work has been further supported by the Sight and Life Global Nutrition Research Institute (Klaus Kraemer), Baltimore, MD, Royal DSM Ltd, Kaiseraugst, Switzerland, and through a Faculty Innovation Award from the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Finally, the authors are thankful to the Hildegard Grunow Foundation for the Rainer Gross Award and the support for the publication of this article. The author(s) received no financial support for the research, authorship, and/or publication of this article.
Funding Information:
The authors are grateful to core members of the Johns Hopkins Nutriproteomics Research Team, including Parul Christian, Robert Cole, Lauren DeVine, John Groopman, Shelly Herbrich, Bareng AS Nonyane, Robert O’Meally, Ingo Ruczinski, Lee Shu-Fune Wu and James Yager. The authors thank the Bill & Melinda Gates Foundation for its support of the original antenatal micronutrient trial and the 7-year postpartum follow-up study (GH614, Ellen Piwoz), and the nutri-proteomics research reported here (OPP5241, Yiwu He). Our work has been further supported by the Sight and Life Global Nutrition Research Institute (Klaus Kraemer), Baltimore, MD, Royal DSM Ltd, Kaiser-augst, Switzerland, and through a Faculty Innovation Award from the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Finally, the authors are thankful to the Hildegard Grunow Foundation for the Rainer Gross Award and the support for the publication of this article.
Publisher Copyright:
© The Author(s) 2019.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Millions of children have multiple nutritional deficiencies, threatening their optimal growth, development, and quality of life. Revealing the magnitude and underlying biology of malnutrition from a greatly expanded set of practical biomarkers will be critical for developing appropriately targeted and evaluated interventions. However, our abilities to reveal and quantify the many forms of malnutrition, other than by anthropometry and occasional use of biochemical indicators, remain limited. Plasma proteomics holds great promise as a basis for developing novel biomarkers to facilitate assessment of growth, micronutrient status, inflammation, and other health status of populations while also providing biological insight into causes and adverse consequences of malnutrition. Discovery-driven plasma proteomics has been shown to reveal functional biomarkers of nutritional and health status, identifying clusters of protein biomarkers from which field-friendly, comprehensive, and low-cost methods could be developed for assessing populations. In this brief review, we summarize several key discoveries to date and discuss potential public health applications of proteomics-based biomarkers in reporting the extent and metabolic features of undernutrition in low-resource settings.
AB - Millions of children have multiple nutritional deficiencies, threatening their optimal growth, development, and quality of life. Revealing the magnitude and underlying biology of malnutrition from a greatly expanded set of practical biomarkers will be critical for developing appropriately targeted and evaluated interventions. However, our abilities to reveal and quantify the many forms of malnutrition, other than by anthropometry and occasional use of biochemical indicators, remain limited. Plasma proteomics holds great promise as a basis for developing novel biomarkers to facilitate assessment of growth, micronutrient status, inflammation, and other health status of populations while also providing biological insight into causes and adverse consequences of malnutrition. Discovery-driven plasma proteomics has been shown to reveal functional biomarkers of nutritional and health status, identifying clusters of protein biomarkers from which field-friendly, comprehensive, and low-cost methods could be developed for assessing populations. In this brief review, we summarize several key discoveries to date and discuss potential public health applications of proteomics-based biomarkers in reporting the extent and metabolic features of undernutrition in low-resource settings.
KW - biomarker
KW - child growth
KW - cognition
KW - inflammation
KW - micronutrients
KW - plasma proteomics
UR - http://www.scopus.com/inward/record.url?scp=85067814407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067814407&partnerID=8YFLogxK
U2 - 10.1177/0379572119847851
DO - 10.1177/0379572119847851
M3 - Article
C2 - 31106587
AN - SCOPUS:85067814407
SN - 0379-5721
VL - 40
SP - 144
EP - 150
JO - Food and nutrition bulletin
JF - Food and nutrition bulletin
IS - 2
ER -