RAGs' eye view of the immunoglobulin heavy chain gene locus

Ramesh Subrahmanyam, Ranjan Sen

Research output: Contribution to journalArticle

Abstract

The immunoglobulin heavy chain (IgH) gene locus is activated at a precise stage of B lymphocyte development to undergo gene rearrangements that assemble the functional gene. In this review we summarize our current understanding of the chromatin state of the IgH as it appears just prior to the initiation of V(D)J recombination, and the implications of this structure for regulation of recombination. We also examine the role of the intron enhancer, Eμ, in establishing the pre-rearrangement chromatin structure. The emerging picture shows that the IgH locus consists of independently regulated domains, each of which requires multiple levels of epigenetic changes to reach the fully activated state.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalSeminars in Immunology
Volume22
Issue number6
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

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Keywords

  • Accessibility
  • Enhancer
  • Epigenetics
  • Immunoglobulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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