Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine

Hayden T. Ravert, Yi Zhang, Andrew Horti, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review


5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)- 2-(2-fluoropyridin-4-yl)vinyl)pyridine ([11C]-FPVC) was synthesized from [11C]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/μmol (9691 mCi/μmole) at end of synthesis (EOS).

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number5
StatePublished - Apr 1 2006


  • Carbon-11
  • Positron emission tomography
  • α4β2 nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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