Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine

Hayden T. Ravert; Yi Zhang; Andrew Horti; Robert F. Dannals

doi:10.1002/jlcr.1064

Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[¹¹C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine

Hayden T. Ravert, Yi Zhang, Andrew Horti, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

5-((1-[¹¹C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)- 2-(2-fluoropyridin-4-yl)vinyl)pyridine ([¹¹C]-FPVC) was synthesized from [¹¹C]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/μmol (9691 mCi/μmole) at end of synthesis (EOS).

Original language	English (US)
Pages (from-to)	459-462
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	49
Issue number	5
DOIs	https://doi.org/10.1002/jlcr.1064
State	Published - Apr 2006

Keywords

Carbon-11
Positron emission tomography
α4β2 nicotinic acetylcholine receptor

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.1064

Cite this

Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[¹¹C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine. / Ravert, Hayden T.; Zhang, Yi; Horti, Andrew et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 49, No. 5, 04.2006, p. 459-462.

Research output: Contribution to journal › Article › peer-review

@article{487175c4fa714c46bb1676b5a2f1ab4a,

title = "Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine",

abstract = "5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)- 2-(2-fluoropyridin-4-yl)vinyl)pyridine ([11C]-FPVC) was synthesized from [11C]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/μmol (9691 mCi/μmole) at end of synthesis (EOS).",

keywords = "Carbon-11, Positron emission tomography, α4β2 nicotinic acetylcholine receptor",

author = "Ravert, {Hayden T.} and Yi Zhang and Andrew Horti and Dannals, {Robert F.}",

year = "2006",

month = apr,

doi = "10.1002/jlcr.1064",

language = "English (US)",

volume = "49",

pages = "459--462",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand

T2 - 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3- ((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine

AU - Ravert, Hayden T.

AU - Zhang, Yi

AU - Horti, Andrew

AU - Dannals, Robert F.

PY - 2006/4

Y1 - 2006/4

N2 - 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)- 2-(2-fluoropyridin-4-yl)vinyl)pyridine ([11C]-FPVC) was synthesized from [11C]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/μmol (9691 mCi/μmole) at end of synthesis (EOS).

AB - 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)- 2-(2-fluoropyridin-4-yl)vinyl)pyridine ([11C]-FPVC) was synthesized from [11C]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/μmol (9691 mCi/μmole) at end of synthesis (EOS).

KW - Carbon-11

KW - Positron emission tomography

KW - α4β2 nicotinic acetylcholine receptor

UR - http://www.scopus.com/inward/record.url?scp=33744938479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744938479&partnerID=8YFLogxK

U2 - 10.1002/jlcr.1064

DO - 10.1002/jlcr.1064

M3 - Article

AN - SCOPUS:33744938479

SN - 0362-4803

VL - 49

SP - 459

EP - 462

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 5

ER -