Radiosynthesis of [11C]paclitaxel

Hayden T. Ravert, Raymond W. Klecker, Jerry M. Collins, William B Mathews, Martin Gilbert Pomper, Richard L. Wahl, Robert F Dannals

Research output: Contribution to journalArticle

Abstract

[11C]paclitaxel, a potential solid tumor imaging agent, was synthesized by reacting [α-11C]benzoyl chloride with the primary amine precursor of paclitaxel. The time for synthesis, purification, and formulation was 38 min from end of bombardment with an average specific radioactivity of 49.9 GBq/μmol (1349 mCi/μmol) at end of synthesis. The average decay corrected radiochemical yield was 7% with greater than 99% radiochemical purity.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume45
Issue number6
DOIs
StatePublished - 2002

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Keywords

  • Anticancer
  • Carbon-11
  • Microtubule
  • Paclitaxel
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

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