Abstract
Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.
Original language | English (US) |
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Pages (from-to) | 305-306 |
Number of pages | 2 |
Journal | International Journal of Radiation Applications and Instrumentation. Part |
Volume | 38 |
Issue number | 4 |
DOIs | |
State | Published - 1987 |
ASJC Scopus subject areas
- Radiation
- General Engineering