Carbon-11 labeled SCH 23390, a selective dopamine D-1 receptor antagonist (Fig. 1b), was prepared by N-alkylation of the nor-methyl precursor with [11C]iodomethane. The product was purified by semi-preparative HPLC and shown to be radiochemically pure at the end of synthesis. The synthesis was completed in approximately 22 min with an average radiochemical yield of 28% (based on [11C]iodomethane) and an average specific activity of approximately 1950 mCi/μmol calculated at the end of synthesis.
|Original language||English (US)|
|Number of pages||2|
|Journal||International Journal of Radiation Applications and Instrumentation. Part|
|State||Published - 1987|
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