Abstract
[11C]-L-753,037, [(+)-(5S,6R,7R)-2-butyl-7-[2-((2S)-2-carboxypropyl)-4-[11C]-methoxyphenyl]- 5-(3,4-methylenedioxyphenyl)-cyclopenteno-[1,2-b]pyridine-6-carboxylate], a potent mixed antagonist of endothelin receptor subtypes ET(A) and ET(B), was synthesized by [11C]-methylation of a phenolic precursor. The time for synthesis, purification, and formulation was 17 minutes with an average specific radioactivity of 2535 mCi/μmol (EOS) and average decay corrected radiochemical yield of 3% based on [11C]-methyl iodide.
Original language | English (US) |
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Pages (from-to) | 1205-1210 |
Number of pages | 6 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 43 |
Issue number | 12 |
DOIs | |
State | Published - 2000 |
Keywords
- Carbon-11
- Endothelin
- L-753,037
- Positron emission tomography
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry