Radiosynthesis of a ligand for studying the glycine transporter: [11C]ALX-5407

Hayden T. Ravert, William B. Mathews, Mark A. Klitenick, Dean F. Wong, Robert F. Dannals

Research output: Contribution to journalArticle

Abstract

[11C]ALX-5407, R-N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [11C]iodomethane by N-alkylation of methyl ester protected N-normethyl precursor, ALX-5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/μmol (EOS) and average decay corrected radiochemical yield of 8%.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume44
Issue number3
DOIs
StatePublished - Mar 19 2001

Keywords

  • ALX-5407
  • Carbon-11
  • GlyT1
  • Glycine
  • Glycine transporter
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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