Radiosynthesis of 3-[18F]fluoropropyl and 4-[ 18F]fluorobenzyl triarylphosphonium ions

Hayden T. Ravert; Igal Madar; Robert F. Dannals

doi:10.1002/jlcr.835

Radiosynthesis of 3-[¹⁸F]fluoropropyl and 4-[ ¹⁸F]fluorobenzyl triarylphosphonium ions

Hayden T. Ravert, Igal Madar, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

3-[¹⁸F]Fluoropropyl-, 4-[¹⁸F]fluorobenzyl- triphenylphosphonium and 4-[¹⁸F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [¹⁸F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/μmole (403 mCi/ μmole) at end of synthesis (EOS).

Original language	English (US)
Pages (from-to)	469-476
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	47
Issue number	8
DOIs	https://doi.org/10.1002/jlcr.835
State	Published - Jul 2004

Keywords

Fluorine-18
Phosphonium
Positron emission tomography

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.835

Cite this

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title = "Radiosynthesis of 3-[18F]fluoropropyl and 4-[ 18F]fluorobenzyl triarylphosphonium ions",

abstract = "3-[18F]Fluoropropyl-, 4-[18F]fluorobenzyl- triphenylphosphonium and 4-[18F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [18F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/μmole (403 mCi/ μmole) at end of synthesis (EOS).",

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T1 - Radiosynthesis of 3-[18F]fluoropropyl and 4-[ 18F]fluorobenzyl triarylphosphonium ions

AU - Ravert, Hayden T.

AU - Madar, Igal

AU - Dannals, Robert F.

PY - 2004/7

Y1 - 2004/7

N2 - 3-[18F]Fluoropropyl-, 4-[18F]fluorobenzyl- triphenylphosphonium and 4-[18F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [18F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/μmole (403 mCi/ μmole) at end of synthesis (EOS).

AB - 3-[18F]Fluoropropyl-, 4-[18F]fluorobenzyl- triphenylphosphonium and 4-[18F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [18F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/μmole (403 mCi/ μmole) at end of synthesis (EOS).

KW - Fluorine-18

KW - Phosphonium

KW - Positron emission tomography

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