Radiosynthesis of 3-[18F]fluoropropyl and 4-[ 18F]fluorobenzyl triarylphosphonium ions

Hayden T. Ravert, Igal Madar, Robert F Dannals

Research output: Contribution to journalArticle

Abstract

3-[18F]Fluoropropyl-, 4-[18F]fluorobenzyl- triphenylphosphonium and 4-[18F]fluorobenzyltris-4- dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [18F]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79 min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9 GB q/μmole (403 mCi/ μmole) at end of synthesis (EOS).

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume47
Issue number8
DOIs
Publication statusPublished - Jul 2004

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Keywords

  • Fluorine-18
  • Phosphonium
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

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