Radiosynthesis of (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[11C]‐methyI‐l,2,3,4‐tetrahydro‐isoquinoline, [11C]A‐69024: A non‐benzazepine antagonist for studying dopamine D1 receptors In vivo using PET

Michael Kassiou, William B. Mathews, John L. Musachio, Hayden T. Ravert, Richard M. Lambrecht, Robert F. Dannals

Research output: Contribution to journalArticle

Abstract

(±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[11C]‐methyl‐1,2,3,4‐tetrahydroisoquinoline, (HCJA‐69024, a selective ligand for the D1 receptor was prepared by N‐alkylation of (±)N‐desmethyl A‐69024 with [11C]methyl iodide in DMF. The radiotracer was purified by semi‐preparative reverse‐phase HPLC. The average specific activity was 1950 mCi/μmol calculated at end‐of‐synthesis (EOS). The average time of synthesis including formulation was 20 minutes.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume34
Issue number5
DOIs
StatePublished - May 1994

Keywords

  • A‐69024
  • PET
  • carbon‐11
  • dopamine D1 receptor
  • radiotracer

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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