Radiosynthesis of σ Receptor Ligands for Positron Emission Tomography: 11C- and 18F-Labeled Guanidines

Alan A. Wilson, Robert F. Dannals, Hayden T. Ravert, Mark S. Sonders, Eckard Weber, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review


A series of analogues of the potent and selective σ receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the σ receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue. Three of these 1-aryl-3-(1-adamantyl)guanidines were radiolabeled—two with carbon-11 and one with fluorine-18. Radiochemical yields and specific activities were sufficient for these radiotracers to be used in positron emission tomography imaging of the haloperidol-sensitive σ receptor.

Original languageEnglish (US)
Pages (from-to)1867-1870
Number of pages4
JournalJournal of medicinal chemistry
Issue number6
StatePublished - Jun 1 1991

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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