Abstract
A series of analogues of the potent and selective σ receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the σ receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue. Three of these 1-aryl-3-(1-adamantyl)guanidines were radiolabeled—two with carbon-11 and one with fluorine-18. Radiochemical yields and specific activities were sufficient for these radiotracers to be used in positron emission tomography imaging of the haloperidol-sensitive σ receptor.
Original language | English (US) |
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Pages (from-to) | 1867-1870 |
Number of pages | 4 |
Journal | Journal of medicinal chemistry |
Volume | 34 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 1991 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery