Radiosynthesis and validation of [Carboxy- 11 C]4-Aminobenzoic acid ([ 11 C]PABA), a PET radiotracer for imaging bacterial infections

Daniel P. Holt, Alvin S. Kalinda, Lauren E. Bambarger, Sanjay K. Jain, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review

Abstract

In this practitioner protocol, the radiochemical synthesis of [ 11 C] PABA is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (14% at end-of-synthesis (EOS)) at high specific activity (molar activity 11 Ci/μmole EOS; 407 GBq/μmole) and high chemical and radiochemical purity as a sterile, pyrogen-free solution suitable for injection conforming to current Good Manufacturing Practice (cGMP) requirements.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume62
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • PABA
  • QC
  • infection
  • synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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