@article{3f3d823470004aad8019c0b286f81af4,
title = "Radiosynthesis and validation of [5-cyano-N-(4-(4-[11C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl) furan-2-carboxamide] ([11C]CPPC), a PET radiotracer for imaging CSF1R, a microglia-specific marker",
abstract = "In this practitioner protocol, the radiochemical synthesis of [11C]CPPC is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (> 60 mCi (2.22 GBq) at end-of-synthesis (EOS)), at high specific activity (molar activity > 11,435 mCi/μmole (423 GBq/μmole) at EOS) and high chemical and radiochemical purity. The entire production conforms to current Good Manufacturing Practice (cGMP) requirements. The final product is formulated as a sterile, pyrogen-free solution suitable for human injection.",
keywords = "CPPC, CSF1R, PET, QC, synthesis",
author = "Mathews, {William B.} and Yunkou Wu and Horti, {Andrew G.} and Ravi Naik and Hall, {Andrew W.} and Holt, {Daniel P.} and Dannals, {Robert F.}",
note = "Funding Information: The authors would like to thank Robert C. Smoot, CNMT, for testing for the presence of pyrogens and Jack Brown for performing sterility testing. This work was supported in part by NIH Grants AG054802, EB024495, and NS041435 and by the Johns Hopkins University Alzheimer's Disease Research Center (Grant AG05146). Funding Information: The authors would like to thank Robert C. Smoot, CNMT, for testing for the presence of pyrogens and Jack Brown for performing sterility testing. This work was supported in part by NIH Grants AG054802, EB024495, and NS041435 and by the Johns Hopkins University Alzheimer's Disease Research Center (Grant AG05146). Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons, Ltd.",
year = "2019",
month = nov,
day = "1",
doi = "10.1002/jlcr.3806",
language = "English (US)",
volume = "62",
pages = "903--908",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "13",
}