TY - GEN
T1 - Radiomics analysis of baseline F-FDG PET/CT images for improved prognosis in nasopharyngeal carcinoma
AU - Lv, Wenbing
AU - Yuan, Qingyu
AU - Wang, Quanshi
AU - Ma, Jianhua
AU - Feng, Qianjin
AU - Chen, Wufan
AU - Rahmim, Arman
AU - Lu, Lijun
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China under grants 61628105, 81501541, the National key research and development program under grant 2016YFC0104003, the Natural Science Foundation of Guangdong Province under grants 2016A030313577, and the Program of Pearl River Young Talents of Science and Technology in Guangzhou under grant 201610010011. *J. Ma, L. Lu (e-mail: jhma@smu.edu.cn, ljlubme@gmail.com) However, to the best of our knowledge, prognostic analysis of NPC from 18F-FDG PET images by using radiomics features has not been investigated. Thus, in the present study, we aim to use pretreatment radiomics features and clinical features as risk factors to evaluate progression-free survival of NPC patients imaged with 18F-FDG PET.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/5/23
Y1 - 2018/5/23
N2 - The purpose of this study is to investigate the prognostic performance of radiomics features on nasopharyngeal carcinoma (NPC) patients imaged with baseline 18F-FDG PET/CT. 128 NPC patients were retrospectively enrolled with 3348 radiomics features and 13 clinical features. Kaplan-Meier analysis was used to estimate progression-free survival (PFS), and log-rank test was used to screen the significant features. Cox proportional hazards regression modal with forward stepwise feature selection was adopted to identify independent predictors of PFS. 24 radiomics features and 8 clinical features were found to be significantly associated with PFS in univariate analysis. Radiomics features HGZE-GLSZM-HLL-32 (p=0.0061, HR: 0.66, 95%CI: 0.49-0.89), as well as clinical features N-stage, M-stage, antibody VCA-IgA and platelet count (PLT) retained the independent prognostic significance for PFS in multivariate analysis. Overall, radiomics features can provide complementary prognostic information for NPC patients imaged with baseline 18F-FDG PET/CT compared to clinical features.
AB - The purpose of this study is to investigate the prognostic performance of radiomics features on nasopharyngeal carcinoma (NPC) patients imaged with baseline 18F-FDG PET/CT. 128 NPC patients were retrospectively enrolled with 3348 radiomics features and 13 clinical features. Kaplan-Meier analysis was used to estimate progression-free survival (PFS), and log-rank test was used to screen the significant features. Cox proportional hazards regression modal with forward stepwise feature selection was adopted to identify independent predictors of PFS. 24 radiomics features and 8 clinical features were found to be significantly associated with PFS in univariate analysis. Radiomics features HGZE-GLSZM-HLL-32 (p=0.0061, HR: 0.66, 95%CI: 0.49-0.89), as well as clinical features N-stage, M-stage, antibody VCA-IgA and platelet count (PLT) retained the independent prognostic significance for PFS in multivariate analysis. Overall, radiomics features can provide complementary prognostic information for NPC patients imaged with baseline 18F-FDG PET/CT compared to clinical features.
KW - Clinical features
KW - F-FDG PET/CT
KW - Nasopharyngeal carcinoma
KW - Prognosis
KW - Progression-free survival
KW - Radiomics
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U2 - 10.1109/ISBI.2018.8363701
DO - 10.1109/ISBI.2018.8363701
M3 - Conference contribution
AN - SCOPUS:85048098968
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 835
EP - 838
BT - 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PB - IEEE Computer Society
T2 - 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
Y2 - 4 April 2018 through 7 April 2018
ER -