Radiomics analysis of baseline F-FDG PET/CT images for improved prognosis in nasopharyngeal carcinoma

Wenbing Lv, Qingyu Yuan, Quanshi Wang, Jianhua Ma, Qianjin Feng, Wufan Chen, Arman Rahmim, Lijun Lu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study is to investigate the prognostic performance of radiomics features on nasopharyngeal carcinoma (NPC) patients imaged with baseline 18F-FDG PET/CT. 128 NPC patients were retrospectively enrolled with 3348 radiomics features and 13 clinical features. Kaplan-Meier analysis was used to estimate progression-free survival (PFS), and log-rank test was used to screen the significant features. Cox proportional hazards regression modal with forward stepwise feature selection was adopted to identify independent predictors of PFS. 24 radiomics features and 8 clinical features were found to be significantly associated with PFS in univariate analysis. Radiomics features HGZE-GLSZM-HLL-32 (p=0.0061, HR: 0.66, 95%CI: 0.49-0.89), as well as clinical features N-stage, M-stage, antibody VCA-IgA and platelet count (PLT) retained the independent prognostic significance for PFS in multivariate analysis. Overall, radiomics features can provide complementary prognostic information for NPC patients imaged with baseline 18F-FDG PET/CT compared to clinical features.

Original languageEnglish (US)
Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PublisherIEEE Computer Society
Pages835-838
Number of pages4
Volume2018-April
ISBN (Electronic)9781538636367
DOIs
StatePublished - May 23 2018
Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
Duration: Apr 4 2018Apr 7 2018

Other

Other15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
CountryUnited States
CityWashington
Period4/4/184/7/18

Keywords

  • F-FDG PET/CT
  • Clinical features
  • Nasopharyngeal carcinoma
  • Prognosis
  • Progression-free survival
  • Radiomics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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