Radiological Dissociation of Alveolar and Vascular Phases of Rejection in Allografted Lungs

Stanley S. Siegelman; Joseph C. Dougherty; Jack W.C. Hagstrom; Shashi B.P. Sinha; Frank J. Veith

doi:10.1016/S0003-4975(10)65104-1

Radiological Dissociation of Alveolar and Vascular Phases of Rejection in Allografted Lungs

Stanley S. Siegelman, Joseph C. Dougherty, Jack W.C. Hagstrom, Shashi B.P. Sinha, Frank J. Veith

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.

Original language	English (US)
Pages (from-to)	127-138
Number of pages	12
Journal	Annals of Thoracic Surgery
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/S0003-4975(10)65104-1
State	Published - Jan 1 1971

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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title = "Radiological Dissociation of Alveolar and Vascular Phases of Rejection in Allografted Lungs",

abstract = "Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.",

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AU - Veith, Frank J.

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