Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine