Radiological Dissociation of Alveolar and Vascular Phases of Rejection in Allografted Lungs

Stanley S. Siegelman, Joseph C. Dougherty, Jack W.C. Hagstrom, Shashi B.P. Sinha, Frank J. Veith

Research output: Contribution to journalArticlepeer-review

Abstract

Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.

Original languageEnglish (US)
Pages (from-to)127-138
Number of pages12
JournalAnnals of Thoracic Surgery
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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