TY - JOUR
T1 - Radiological Dissociation of Alveolar and Vascular Phases of Rejection in Allografted Lungs
AU - Siegelman, Stanley S.
AU - Dougherty, Joseph C.
AU - Hagstrom, Jack W.C.
AU - Sinha, Shashi B.P.
AU - Veith, Frank J.
PY - 1971/1/1
Y1 - 1971/1/1
N2 - Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.
AB - Twelve dogs with allografted lungs were treated with azathioprine and rabbit antidog thymocyte serum. Chest roentgenography, pulmonary angiography, and lung biopsy revealed a dissociation of the alveolar and vascular components of rejection in 7 of the animals. The vascular phase of rejection was more effectively suppressed than the alveolar phase. This dissociation may produce a functional disturbance with a decreased ventilation to perfusion ratio within the allograft such as has been observed in human lung transplant recipients. The results of this investigation suggest that rejection plays a more important role than previously recognized in the ventilation-perfusion imbalance that occurs with pulmonary allografts.
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U2 - 10.1016/S0003-4975(10)65104-1
DO - 10.1016/S0003-4975(10)65104-1
M3 - Article
C2 - 4934812
AN - SCOPUS:0015106428
VL - 12
SP - 127
EP - 138
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 2
ER -