Radiologic and Pathologic Correlation of Invasive Lobular Carcinoma of the Breast

Eniola Oluyemi, Ani Peshtani, Marissa J. White, Ashley Cimino-Mathews

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The primary goal of this review is to give an update on the radiologic and pathologic features of invasive lobular carcinoma (ILC), with an emphasis on recent studies related to the diagnosis of ILC. We review the imaging features of ILC and also discuss recommendations for avoiding potential pitfalls that can result in a delayed diagnosis. The histologic features of ILC and the role of multidisciplinary radiographic-pathologic correlation in aiding a timely diagnosis of ILC are also discussed. Recent Findings: There have been recent technologic advancements in breast imaging, including digital breast tomosynthesis, molecular breast imaging, and contrast-enhanced digital mammography, all of which have been shown to outperform conventional digital mammography in the diagnosis of ILC. Summary: The imaging features of ILC can be subtle due to its lack of significant desmoplastic response, thus making it challenging to diagnose. This underscores the importance of careful radiologic-pathologic correlation and appropriate management of suspicious imaging findings and suspicious clinical findings even in the absence of a correlating imaging abnormality.

Original languageEnglish (US)
JournalCurrent Breast Cancer Reports
StateAccepted/In press - 2021


  • Invasive lobular carcinoma
  • Lobular carcinoma in situ
  • Radiographic-pathologic correlation

ASJC Scopus subject areas

  • Oncology


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