Radioligands for the angiotensin II subtype 1 (AT1) receptor

William B. Mathews; Zsolt Szabo

doi:10.2174/156802610793176729

Radioligands for the angiotensin II subtype 1 (AT1) receptor

William B. Mathews, Zsolt Szabo

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Over the last years, ligands for angiotensin II subtype 1 receptor (AT1R) have been developed as an alternative to the use of angiotensin-converting enzyme (ACE) inhibitors for controlling high blood pressure. Radiolabeled versions of these ligands have proven vital to the development of more potent and specific drugs for the treatment of hypertension. Imaging studies using radiolabeled AT1R ligands have also elucidated the role these receptors play in angiogenesis as well as in various disease states beyond hypertension.

Original language	English (US)
Pages (from-to)	1585-1599
Number of pages	15
Journal	Current topics in medicinal chemistry
Volume	10
Issue number	16
DOIs	https://doi.org/10.2174/156802610793176729
State	Published - 2010

Keywords

AT1
Angiotensin
Carbon-11
Hypertension
Iodine-125
Losartan
Radioligand
Tritium

ASJC Scopus subject areas

Drug Discovery

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10.2174/156802610793176729

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AB - Over the last years, ligands for angiotensin II subtype 1 receptor (AT1R) have been developed as an alternative to the use of angiotensin-converting enzyme (ACE) inhibitors for controlling high blood pressure. Radiolabeled versions of these ligands have proven vital to the development of more potent and specific drugs for the treatment of hypertension. Imaging studies using radiolabeled AT1R ligands have also elucidated the role these receptors play in angiogenesis as well as in various disease states beyond hypertension.

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KW - Carbon-11

KW - Hypertension

KW - Iodine-125

KW - Losartan

KW - Radioligand

KW - Tritium

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Radioligands for the angiotensin II subtype 1 (AT1) receptor

Abstract

Keywords

ASJC Scopus subject areas

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