Two radioiodinated analogs of benzoylcholine were investigated as possible myocardial‐imaging agents. O‐([2‐125I]iodobenzoyl)choline and N‐([2‐125I]iodobenzoyl)cholamine were prepared by nucleophilic substitution of sodium [125I] iodide for stable iodine in O‐(N,N‐dimethylaminoethyl)‐2‐iodobenzoate and N‐(N', N'‐dimethyiaminoethyl)‐2‐iodobenzamide, respectively, and by methylation with methyl iodide. The in vivo distribution of each compound in mice was determined as a function of time. Favorable heart‐to‐blood and heart‐to‐lung ratios were obtained with N‐([2‐125I]iodobenzoyl)cholamine.
- Benzoylcholine, radioiodinated analogs—synthesized and evaluated as possible myocardial‐imaging agents, biodistribution studies in mice
- Biodistribution—radioiodinated benzoylcholine analogs synthesized and evaluated for use as myocardial‐imaging agents, mice
- Radionuclide imaging, myocardial—radioiodinated benzoylcholine analogs synthesized and evaluated for use as myocardial‐imaging agents, mice
- Radiopharmaceuticals, iodinated—benzoylcholine analogs, synthesis and evaluation for use as myocardial‐imaging agents, mice
ASJC Scopus subject areas
- Pharmaceutical Science