Radiolabeled benzoylcholine derivatives as possible myocardial‐imaging agents

Robert F. Dannals, H. Donald Burns, Luigi G. Marzilli, Timothy C. Trageser, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Two radioiodinated analogs of benzoylcholine were investigated as possible myocardial‐imaging agents. O‐([2‐125I]iodobenzoyl)choline and N‐([2‐125I]iodobenzoyl)cholamine were prepared by nucleophilic substitution of sodium [125I] iodide for stable iodine in O‐(N,N‐dimethylaminoethyl)‐2‐iodobenzoate and N‐(N', N'‐dimethyiaminoethyl)‐2‐iodobenzamide, respectively, and by methylation with methyl iodide. The in vivo distribution of each compound in mice was determined as a function of time. Favorable heart‐to‐blood and heart‐to‐lung ratios were obtained with N‐([2‐125I]iodobenzoyl)cholamine.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume70
Issue number4
DOIs
StatePublished - Apr 1981

Keywords

  • Benzoylcholine, radioiodinated analogs—synthesized and evaluated as possible myocardial‐imaging agents, biodistribution studies in mice
  • Biodistribution—radioiodinated benzoylcholine analogs synthesized and evaluated for use as myocardial‐imaging agents, mice
  • Radionuclide imaging, myocardial—radioiodinated benzoylcholine analogs synthesized and evaluated for use as myocardial‐imaging agents, mice
  • Radiopharmaceuticals, iodinated—benzoylcholine analogs, synthesis and evaluation for use as myocardial‐imaging agents, mice

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Radiolabeled benzoylcholine derivatives as possible myocardial‐imaging agents'. Together they form a unique fingerprint.

Cite this