Radioimmunotherapy with alpha-particle-emitting immunoconjugates

Roger M. Macklis, Berma M. Kinsey, Amin I. Kassis, James L.M. Ferrara, Robert W. Atcher, John J. Hines, C. Norman Coleman, S. James Adelstein, Steven J. Burakoff

Research output: Contribution to journalArticlepeer-review

Abstract

Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An α-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2+ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cells reduced the uptake of [3H]thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy.

Original languageEnglish (US)
Pages (from-to)1024-1026
Number of pages3
JournalScience
Volume240
Issue number4855
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • General

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