Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection

Ruth A. Bryan, Zewei Jiang, Robertha C. Howell, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadeval, Ekaterina Dadachova

Research output: Contribution to journalArticle

Abstract

Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with 213Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated colonyforming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number4
DOIs
StatePublished - Aug 15 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Bryan, R. A., Jiang, Z., Howell, R. C., Morgenstern, A., Bruchertseifer, F., Casadeval, A., & Dadachova, E. (2010). Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection. Journal of Infectious Diseases, 202(4), 633-637. https://doi.org/10.1086/654813