TY - JOUR
T1 - Radioimmunotherapy is more effective than antifungal treatment in experimental Cryptococcal Infection
AU - Bryan, Ruth A.
AU - Jiang, Zewei
AU - Howell, Robertha C.
AU - Morgenstern, Alfred
AU - Bruchertseifer, Frank
AU - Casadeval, Arturo
AU - Dadachova, Ekaterina
N1 - Funding Information:
Received 22 September 2009; accepted 7 January 2010; electronically published 1 July 2010. Potential conflicts of interest: none reported. Presented in part: 109th American Society for Microbiology General Meeting, Philadelphia, PA, 17–21 May 2009 (abstract F-019). Financial support: National Institutes of Health (grant AI60507 to E.D. and grants AI33774-11, HL59842-07, AI33142-11, AI52733-02, and GM 07142-01 to A.C.); Fighting Children’s Cancers Foundation (grant to E.D.); European Commission (grants to A.M. and F.B.). Reprints or correspondence: Dr Ekaterina Dadachova, Albert Einstein College of Medicine, Department of Nuclear Medicine, 1695A Eastchester Rd, Bronx, NY 10461 (ekaterina .dadachova@einstein.yu.edu).
PY - 2010/8/15
Y1 - 2010/8/15
N2 - Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with 213Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated colonyforming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.
AB - Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with 213Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. 213Bi-18B7 treatment almost completely eliminated colonyforming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.
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U2 - 10.1086/654813
DO - 10.1086/654813
M3 - Article
C2 - 20594103
AN - SCOPUS:77954690760
SN - 0022-1899
VL - 202
SP - 633
EP - 637
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -