Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

Martinus W.A. de Jonge; Jos G.W. Kosterink; Yu Yan Bin; Jeff W.M. Bulte; Roland A.M. Kengen; Do A. Piers; T. Hauw The; Lou de Leij

doi:10.1016/0959-8049(93)90543-O

Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using ¹¹¹in-labelled monoclonal antibody MOC-31

Martinus W.A. de Jonge, Jos G.W. Kosterink, Yu Yan Bin, Jeff W.M. Bulte, Roland A.M. Kengen, Do A. Piers, T. Hauw The, Lou de Leij

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11 Scopus citations

Abstract

The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [¹¹¹In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

Original language	English (US)
Pages (from-to)	1885-1890
Number of pages	6
Journal	European Journal of Cancer
Volume	29
Issue number	13
DOIs	https://doi.org/10.1016/0959-8049(93)90543-O
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0959-8049(93)90543-O

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@article{65b47064adc046409451ae5eeb008d59,

title = "Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31",

abstract = "The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.",

author = "{de Jonge}, {Martinus W.A.} and Kosterink, {Jos G.W.} and Bin, {Yu Yan} and Bulte, {Jeff W.M.} and Kengen, {Roland A.M.} and Piers, {Do A.} and {Hauw The}, T. and {de Leij}, Lou",

year = "1993",

doi = "10.1016/0959-8049(93)90543-O",

language = "English (US)",

volume = "29",

pages = "1885--1890",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "13",

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TY - JOUR

T1 - Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

AU - de Jonge, Martinus W.A.

AU - Kosterink, Jos G.W.

AU - Bin, Yu Yan

AU - Bulte, Jeff W.M.

AU - Kengen, Roland A.M.

AU - Piers, Do A.

AU - Hauw The, T.

AU - de Leij, Lou

PY - 1993

Y1 - 1993

N2 - The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

AB - The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

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DO - 10.1016/0959-8049(93)90543-O

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AN - SCOPUS:0027425447

SN - 0959-8049

VL - 29

SP - 1885

EP - 1890

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 13

ER -

Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using ¹¹¹in-labelled monoclonal antibody MOC-31

Abstract

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