Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

Martinus W A de Jonge, Jos G W Kosterink, Yu Yan Bin, Jeff W Bulte, Roland A M Kengen, Do A. Piers, T. Hauw The, Lou de Leij

Research output: Contribution to journalArticle

Abstract

The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

Original languageEnglish (US)
Pages (from-to)1885-1890
Number of pages6
JournalEuropean Journal of Cancer
Volume29
Issue number13
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Radioimmunodetection
Nude Rats
Small Cell Lung Carcinoma
Heterografts
Monoclonal Antibodies
Antigens
Pentetic Acid
Equipment and Supplies
Membranes
Antibodies
Liver
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31. / de Jonge, Martinus W A; Kosterink, Jos G W; Bin, Yu Yan; Bulte, Jeff W; Kengen, Roland A M; Piers, Do A.; Hauw The, T.; de Leij, Lou.

In: European Journal of Cancer, Vol. 29, No. 13, 1993, p. 1885-1890.

Research output: Contribution to journalArticle

de Jonge, Martinus W A ; Kosterink, Jos G W ; Bin, Yu Yan ; Bulte, Jeff W ; Kengen, Roland A M ; Piers, Do A. ; Hauw The, T. ; de Leij, Lou. / Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31. In: European Journal of Cancer. 1993 ; Vol. 29, No. 13. pp. 1885-1890.
@article{65b47064adc046409451ae5eeb008d59,
title = "Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31",
abstract = "The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.",
author = "{de Jonge}, {Martinus W A} and Kosterink, {Jos G W} and Bin, {Yu Yan} and Bulte, {Jeff W} and Kengen, {Roland A M} and Piers, {Do A.} and {Hauw The}, T. and {de Leij}, Lou",
year = "1993",
doi = "10.1016/0959-8049(93)90543-O",
language = "English (US)",
volume = "29",
pages = "1885--1890",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "13",

}

TY - JOUR

T1 - Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

AU - de Jonge, Martinus W A

AU - Kosterink, Jos G W

AU - Bin, Yu Yan

AU - Bulte, Jeff W

AU - Kengen, Roland A M

AU - Piers, Do A.

AU - Hauw The, T.

AU - de Leij, Lou

PY - 1993

Y1 - 1993

N2 - The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

AB - The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

UR - http://www.scopus.com/inward/record.url?scp=0027425447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027425447&partnerID=8YFLogxK

U2 - 10.1016/0959-8049(93)90543-O

DO - 10.1016/0959-8049(93)90543-O

M3 - Article

C2 - 8260247

AN - SCOPUS:0027425447

VL - 29

SP - 1885

EP - 1890

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 13

ER -