Radioimmunodetection of human small cell lung carcinoma xenografts in the nude rat using 111in-labelled monoclonal antibody MOC-31

Martinus W.A. de Jonge, Jos G.W. Kosterink, Yu Yan Bin, Jeff W.M. Bulte, Roland A.M. Kengen, Do A. Piers, T. Hauw The, Lou de Leij

Research output: Contribution to journalArticlepeer-review

Abstract

The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pancarcinoma membrane antigen. [111In]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

Original languageEnglish (US)
Pages (from-to)1885-1890
Number of pages6
JournalEuropean Journal of Cancer
Volume29
Issue number13
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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