Radiogenomics and Its Role in Lymphoma

Saman Khan, Sohaib Naim, Rania Bilwani, Amirah Salem, David Gorlin, Ahmad Muhammad, Maryam Gul, Muhammad H. Imam, Ammar Chaudhry

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of Review: Imaging features of lymphoma vary regionally. Awareness of site-specific key imaging characteristics of lymphoma can aid in rapid staging and assist in prompt treatment. FDG PET/CT and conventional MRI are readily available diagnostic modalities with excellent sensitivity and good specificity. Diagnostic specificity can be enhanced using emerging PET radiotracers, e.g., FLT and FET. Recent Findings: Emerging research has shown higher dimensional analysis (radiomics and radiogenomics) of imaging data can yield information of the underlying genetic aberrations in lymphoma, which can aid in assessing real-time evolution of tumor. Summary: CT, PET/CT, MRI, and ultrasound accentuate the intrinsic qualities of lymphoma (e.g., FDG PET/CT for increased metabolic activity, FLT PET/CT for increased proliferation index, and DWI for increased cellularity) and play an essential role in its diagnosis and examination. Advanced radiogenomic analyses use radiomic parameters to deduce genetic variations of lymphoma, providing noninvasive, repeatable, and real-time surveillance of its genetic progression.

Original languageEnglish (US)
Pages (from-to)211-224
Number of pages14
JournalCurrent Hematologic Malignancy Reports
Volume15
Issue number3
DOIs
StatePublished - Jun 1 2020
Externally publishedYes

Keywords

  • Hodgkin’s lymphoma
  • Imaging biomarkers
  • Lymphoma
  • Non-Hodgkin’s lymphoma
  • Radiogenomics
  • Radiomics

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Radiogenomics and Its Role in Lymphoma'. Together they form a unique fingerprint.

Cite this