Radiofrequency thermal ablation: 3D MR-histology correlation for localization of cell death in MR lesion images

D. L. Wilson, M. S. Breen, R. S. Lazebnik, S. Nour, J. S. Lewin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Solid tumors are being treated using radiofrequency (RF) thermal ablation under interventional MRI image guidance. We are investigating the ability of MR to accurately predict the region of cell death by comparing MR thermal lesion images to tissue damage as seen histologically. We developed a methodology using a three-dimensional computer registration. An open MR imaging system was used to guide an RF ablation electrode into rabbit thigh muscles, and acquire in vivo post-ablation MR volumes. After MR and histology images were registered with an accuracy of 1.32 ± 0.39 mm (mean ± SD), we compared a boundary of necrosis identified in histology with the outer boundary of the hyperintense rim in MR images. For 14 T2-weighted MR images, the absolute distance between boundaries was 0.96 ± 0.34 mm. Similar correlations were obtained from experiments with rabbits sacrificed four days post-ablation. This is good evidence that during ablation treatments, MR images can accurately identify the necrotic region.

Original languageEnglish (US)
Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationMacro to Nano
Pages1537-1540
Number of pages4
StatePublished - Dec 1 2004
Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
Duration: Apr 15 2004Apr 18 2004

Publication series

Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume2

Other

Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
CountryUnited States
CityArlington, VA
Period4/15/044/18/04

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Radiofrequency thermal ablation: 3D MR-histology correlation for localization of cell death in MR lesion images'. Together they form a unique fingerprint.

  • Cite this

    Wilson, D. L., Breen, M. S., Lazebnik, R. S., Nour, S., & Lewin, J. S. (2004). Radiofrequency thermal ablation: 3D MR-histology correlation for localization of cell death in MR lesion images. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1537-1540). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).