Radioembolization with 90Y microspheres: Angiographic and technical considerations

Robert J. Lewandowski; Kent T. Sato; Bassel Atassi; Robert K. Ryu; Albert A. Nemcek; Laura Kulik; Jean Francois Geschwind; Ravi Murthy; William Rilling; David Liu; Lourens Bester; Jose Ignacio Bilbao; Andrew S. Kennedy; Reed A. Omary; Riad Salem

doi:10.1007/s00270-007-9064-z

Radioembolization with ⁹⁰Y microspheres: Angiographic and technical considerations

Robert J. Lewandowski, Kent T. Sato, Bassel Atassi, Robert K. Ryu, Albert A. Nemcek, Laura Kulik, Jean Francois Geschwind, Ravi Murthy, William Rilling, David Liu, Lourens Bester, Jose Ignacio Bilbao, Andrew S. Kennedy, Reed A. Omary, Riad Salem

School of Medicine

Research output: Contribution to journal › Review article › peer-review

211 Scopus citations

Abstract

The anatomy of the mesenteric system and the hepatic arterial bed has been demonstrated to have a high degree of variation. This is important when considering pre-surgical planning, catheterization, and trans-arterial hepatic therapies. Although anatomical variants have been well described, the characterization and understanding of regional hepatic perfusion in the context of radioembolization have not been studied with great depth. The purpose of this review is to provide a thorough discussion and detailed presentation of the angiographic and technical aspects of radioembolization. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. Furthermore, the principles described here apply to all liver-directed transarterial therapies.

Original language	English (US)
Pages (from-to)	571-592
Number of pages	22
Journal	Cardiovascular and interventional radiology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/s00270-007-9064-z
State	Published - Jul 2007

Keywords

Brachytherapy
Embolization
Liver cancer
Radioembolization
SIR-Spheres
Selective internal radiation
TheraSphere
Yttrium-90

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s00270-007-9064-z

Cite this

Lewandowski, R. J., Sato, K. T., Atassi, B., Ryu, R. K., Nemcek, A. A., Kulik, L., Geschwind, J. F., Murthy, R., Rilling, W., Liu, D., Bester, L., Bilbao, J. I., Kennedy, A. S., Omary, R. A., & Salem, R. (2007). Radioembolization with ⁹⁰Y microspheres: Angiographic and technical considerations. Cardiovascular and interventional radiology, 30(4), 571-592. https://doi.org/10.1007/s00270-007-9064-z

Lewandowski, RJ, Sato, KT, Atassi, B, Ryu, RK, Nemcek, AA, Kulik, L, Geschwind, JF, Murthy, R, Rilling, W, Liu, D, Bester, L, Bilbao, JI, Kennedy, AS, Omary, RA & Salem, R 2007, 'Radioembolization with ⁹⁰Y microspheres: Angiographic and technical considerations', Cardiovascular and interventional radiology, vol. 30, no. 4, pp. 571-592. https://doi.org/10.1007/s00270-007-9064-z

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abstract = "The anatomy of the mesenteric system and the hepatic arterial bed has been demonstrated to have a high degree of variation. This is important when considering pre-surgical planning, catheterization, and trans-arterial hepatic therapies. Although anatomical variants have been well described, the characterization and understanding of regional hepatic perfusion in the context of radioembolization have not been studied with great depth. The purpose of this review is to provide a thorough discussion and detailed presentation of the angiographic and technical aspects of radioembolization. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. Furthermore, the principles described here apply to all liver-directed transarterial therapies.",

keywords = "Brachytherapy, Embolization, Liver cancer, Radioembolization, SIR-Spheres, Selective internal radiation, TheraSphere, Yttrium-90",

author = "Lewandowski, {Robert J.} and Sato, {Kent T.} and Bassel Atassi and Ryu, {Robert K.} and Nemcek, {Albert A.} and Laura Kulik and Geschwind, {Jean Francois} and Ravi Murthy and William Rilling and David Liu and Lourens Bester and Bilbao, {Jose Ignacio} and Kennedy, {Andrew S.} and Omary, {Reed A.} and Riad Salem",

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AU - Ryu, Robert K.

AU - Nemcek, Albert A.

AU - Kulik, Laura

AU - Geschwind, Jean Francois

AU - Murthy, Ravi

AU - Rilling, William

AU - Liu, David

AU - Bester, Lourens

AU - Bilbao, Jose Ignacio

AU - Kennedy, Andrew S.

AU - Omary, Reed A.

AU - Salem, Riad

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AB - The anatomy of the mesenteric system and the hepatic arterial bed has been demonstrated to have a high degree of variation. This is important when considering pre-surgical planning, catheterization, and trans-arterial hepatic therapies. Although anatomical variants have been well described, the characterization and understanding of regional hepatic perfusion in the context of radioembolization have not been studied with great depth. The purpose of this review is to provide a thorough discussion and detailed presentation of the angiographic and technical aspects of radioembolization. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. Furthermore, the principles described here apply to all liver-directed transarterial therapies.

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KW - Embolization

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KW - SIR-Spheres

KW - Selective internal radiation

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KW - Yttrium-90

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