Radioactive seed localization for non-palpable breast cancer

M. W. Barentsz, M. A A J Van Den Bosch, W. B. Veldhuis, P. J. Van Diest, R. M. Pijnappel, A. J. Witkamp, H. M. Verkooijen

Research output: Contribution to journalArticle

Abstract

Background Radioactive seed localization (RSL) is an alternative to wire localization for guiding surgical excision of non-palpable breast cancer. This review provides an overview of the available evidence on the accuracy of RSL in patients undergoing breast-conserving surgery. Methods PubMed, Embase and the Cochrane Library were searched systematically in January 2012 for studies that addressed localization of non-palpable breast cancer using an iodine-125-labelled seed. Studies were deemed eligible if they reported on the proportion of patients with tumour-positive margins after RSL, the proportion of patients needing re-excision after RSL, and procedural complications. Results Six studies reported data on RSL in 1611 patients with non-palpable breast lesions. Overall complete resection rates ranged from 73 to 96·7 per cent. Three studies included over 300 patients, and complete resection rates in these studies varied between 89·5 and 96·7 per cent. The risk of seed migration and failure of seed placement ranged from 0 to 0·6 per cent and 0 to 7·2 per cent respectively. Conclusion Available scientific evidence suggests that RSL is a safe and accurate technique for localization of non-palpable breast lesions.

Original languageEnglish (US)
Pages (from-to)582-588
Number of pages7
JournalBritish Journal of Surgery
Volume100
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

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Seeds
Breast Neoplasms
Breast
Segmental Mastectomy
PubMed
Iodine
Libraries
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Barentsz, M. W., Van Den Bosch, M. A. A. J., Veldhuis, W. B., Van Diest, P. J., Pijnappel, R. M., Witkamp, A. J., & Verkooijen, H. M. (2013). Radioactive seed localization for non-palpable breast cancer. British Journal of Surgery, 100(5), 582-588. https://doi.org/10.1002/bjs.9068

Radioactive seed localization for non-palpable breast cancer. / Barentsz, M. W.; Van Den Bosch, M. A A J; Veldhuis, W. B.; Van Diest, P. J.; Pijnappel, R. M.; Witkamp, A. J.; Verkooijen, H. M.

In: British Journal of Surgery, Vol. 100, No. 5, 2013, p. 582-588.

Research output: Contribution to journalArticle

Barentsz, MW, Van Den Bosch, MAAJ, Veldhuis, WB, Van Diest, PJ, Pijnappel, RM, Witkamp, AJ & Verkooijen, HM 2013, 'Radioactive seed localization for non-palpable breast cancer', British Journal of Surgery, vol. 100, no. 5, pp. 582-588. https://doi.org/10.1002/bjs.9068
Barentsz MW, Van Den Bosch MAAJ, Veldhuis WB, Van Diest PJ, Pijnappel RM, Witkamp AJ et al. Radioactive seed localization for non-palpable breast cancer. British Journal of Surgery. 2013;100(5):582-588. https://doi.org/10.1002/bjs.9068
Barentsz, M. W. ; Van Den Bosch, M. A A J ; Veldhuis, W. B. ; Van Diest, P. J. ; Pijnappel, R. M. ; Witkamp, A. J. ; Verkooijen, H. M. / Radioactive seed localization for non-palpable breast cancer. In: British Journal of Surgery. 2013 ; Vol. 100, No. 5. pp. 582-588.
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