Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer

S. Van Esser, M. Hobbelink, I. M C Van Der Ploeg, W. P T H M Mali, P. J. Van Diest, I. H M Borel Rinkes, R. Van Hillegersberg

Research output: Contribution to journalArticle

Abstract

Background: Wire guided localization (WGL) for non-palpable breast cancer is technically difficult and patient unfriendly. Radio guided occult lesion localization (ROLL) takes advantage of the possibility to detect the tumor through the nuclear tracer that is injected directly into the tumor for the sentinel node procedure. Methods: Forty patients with 41 invasive breast carcinomas were treated using ROLL. Patients received a dose of 120Mbq 99mTc Nanocolloid intra-tumorally on the day of surgery or a dose of 370Mbq 99mTc Nanocolloïd intra-tumorally the prior day. The sentinel node (SN) was located using patent blue and a gamma ray detection probe that was also employed to guide the tumor excision. Results: In 31 patients (78%) the invasive tumor was adequately excised. In two cases (5%) a re-excision was required due to inadequately excised carcinoma in situ and in three patients (7.5%) both the invasive and the in situ tumor were inadequately excised. In 35 patients (88%) the SN was found and removed. Conclusions: The ROLL procedure seems to be an alternative to WGL in patients with non-palpable breast carcinoma. To determine the place of ROLL versus WGL in the treatment of non-palpable breast cancer, a randomized clinical trial is needed.

Original languageEnglish (US)
Pages (from-to)526-529
Number of pages4
JournalJournal of Surgical Oncology
Volume98
Issue number7
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Fingerprint

Radio
Breast Neoplasms
Neoplasms
Gamma Rays
Carcinoma in Situ
Ambulatory Surgical Procedures
Randomized Controlled Trials
cyhalothrin

Keywords

  • 99m Tc-nanocolloid
  • Non-palpable breast cancer
  • Radioguided surgery
  • ROLL technique
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Van Esser, S., Hobbelink, M., Van Der Ploeg, I. M. C., Mali, W. P. T. H. M., Van Diest, P. J., Borel Rinkes, I. H. M., & Van Hillegersberg, R. (2008). Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer. Journal of Surgical Oncology, 98(7), 526-529. https://doi.org/10.1002/jso.21143

Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer. / Van Esser, S.; Hobbelink, M.; Van Der Ploeg, I. M C; Mali, W. P T H M; Van Diest, P. J.; Borel Rinkes, I. H M; Van Hillegersberg, R.

In: Journal of Surgical Oncology, Vol. 98, No. 7, 01.12.2008, p. 526-529.

Research output: Contribution to journalArticle

Van Esser, S, Hobbelink, M, Van Der Ploeg, IMC, Mali, WPTHM, Van Diest, PJ, Borel Rinkes, IHM & Van Hillegersberg, R 2008, 'Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer', Journal of Surgical Oncology, vol. 98, no. 7, pp. 526-529. https://doi.org/10.1002/jso.21143
Van Esser S, Hobbelink M, Van Der Ploeg IMC, Mali WPTHM, Van Diest PJ, Borel Rinkes IHM et al. Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer. Journal of Surgical Oncology. 2008 Dec 1;98(7):526-529. https://doi.org/10.1002/jso.21143
Van Esser, S. ; Hobbelink, M. ; Van Der Ploeg, I. M C ; Mali, W. P T H M ; Van Diest, P. J. ; Borel Rinkes, I. H M ; Van Hillegersberg, R. / Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer. In: Journal of Surgical Oncology. 2008 ; Vol. 98, No. 7. pp. 526-529.
@article{5c1c47f8b8c64973828bf7f96f3bd313,
title = "Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer",
abstract = "Background: Wire guided localization (WGL) for non-palpable breast cancer is technically difficult and patient unfriendly. Radio guided occult lesion localization (ROLL) takes advantage of the possibility to detect the tumor through the nuclear tracer that is injected directly into the tumor for the sentinel node procedure. Methods: Forty patients with 41 invasive breast carcinomas were treated using ROLL. Patients received a dose of 120Mbq 99mTc Nanocolloid intra-tumorally on the day of surgery or a dose of 370Mbq 99mTc Nanocollo{\"i}d intra-tumorally the prior day. The sentinel node (SN) was located using patent blue and a gamma ray detection probe that was also employed to guide the tumor excision. Results: In 31 patients (78{\%}) the invasive tumor was adequately excised. In two cases (5{\%}) a re-excision was required due to inadequately excised carcinoma in situ and in three patients (7.5{\%}) both the invasive and the in situ tumor were inadequately excised. In 35 patients (88{\%}) the SN was found and removed. Conclusions: The ROLL procedure seems to be an alternative to WGL in patients with non-palpable breast carcinoma. To determine the place of ROLL versus WGL in the treatment of non-palpable breast cancer, a randomized clinical trial is needed.",
keywords = "99m Tc-nanocolloid, Non-palpable breast cancer, Radioguided surgery, ROLL technique, Sentinel lymph node biopsy",
author = "{Van Esser}, S. and M. Hobbelink and {Van Der Ploeg}, {I. M C} and Mali, {W. P T H M} and {Van Diest}, {P. J.} and {Borel Rinkes}, {I. H M} and {Van Hillegersberg}, R.",
year = "2008",
month = "12",
day = "1",
doi = "10.1002/jso.21143",
language = "English (US)",
volume = "98",
pages = "526--529",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Radio guided occult lesion localization (ROLL) for non-palpable invasive breast cancer

AU - Van Esser, S.

AU - Hobbelink, M.

AU - Van Der Ploeg, I. M C

AU - Mali, W. P T H M

AU - Van Diest, P. J.

AU - Borel Rinkes, I. H M

AU - Van Hillegersberg, R.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: Wire guided localization (WGL) for non-palpable breast cancer is technically difficult and patient unfriendly. Radio guided occult lesion localization (ROLL) takes advantage of the possibility to detect the tumor through the nuclear tracer that is injected directly into the tumor for the sentinel node procedure. Methods: Forty patients with 41 invasive breast carcinomas were treated using ROLL. Patients received a dose of 120Mbq 99mTc Nanocolloid intra-tumorally on the day of surgery or a dose of 370Mbq 99mTc Nanocolloïd intra-tumorally the prior day. The sentinel node (SN) was located using patent blue and a gamma ray detection probe that was also employed to guide the tumor excision. Results: In 31 patients (78%) the invasive tumor was adequately excised. In two cases (5%) a re-excision was required due to inadequately excised carcinoma in situ and in three patients (7.5%) both the invasive and the in situ tumor were inadequately excised. In 35 patients (88%) the SN was found and removed. Conclusions: The ROLL procedure seems to be an alternative to WGL in patients with non-palpable breast carcinoma. To determine the place of ROLL versus WGL in the treatment of non-palpable breast cancer, a randomized clinical trial is needed.

AB - Background: Wire guided localization (WGL) for non-palpable breast cancer is technically difficult and patient unfriendly. Radio guided occult lesion localization (ROLL) takes advantage of the possibility to detect the tumor through the nuclear tracer that is injected directly into the tumor for the sentinel node procedure. Methods: Forty patients with 41 invasive breast carcinomas were treated using ROLL. Patients received a dose of 120Mbq 99mTc Nanocolloid intra-tumorally on the day of surgery or a dose of 370Mbq 99mTc Nanocolloïd intra-tumorally the prior day. The sentinel node (SN) was located using patent blue and a gamma ray detection probe that was also employed to guide the tumor excision. Results: In 31 patients (78%) the invasive tumor was adequately excised. In two cases (5%) a re-excision was required due to inadequately excised carcinoma in situ and in three patients (7.5%) both the invasive and the in situ tumor were inadequately excised. In 35 patients (88%) the SN was found and removed. Conclusions: The ROLL procedure seems to be an alternative to WGL in patients with non-palpable breast carcinoma. To determine the place of ROLL versus WGL in the treatment of non-palpable breast cancer, a randomized clinical trial is needed.

KW - 99m Tc-nanocolloid

KW - Non-palpable breast cancer

KW - Radioguided surgery

KW - ROLL technique

KW - Sentinel lymph node biopsy

UR - http://www.scopus.com/inward/record.url?scp=56649113040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56649113040&partnerID=8YFLogxK

U2 - 10.1002/jso.21143

DO - 10.1002/jso.21143

M3 - Article

C2 - 18767074

AN - SCOPUS:56649113040

VL - 98

SP - 526

EP - 529

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 7

ER -