Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas

Donald E. Thrall, Deborah M. Prescott, Thaddeus V. Samulski, Gary Rosner, David L. Denman, Roberto L. Legorreta, Richard K. Dodge, Rodney L. Page, J. Mark Cline, Jihjong Lee, Beth C. Case, Sydney M. Evans, James R. Oleson, Mark W. Dewhirst

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p <0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.

Original languageEnglish (US)
Pages (from-to)1087-1096
Number of pages10
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume34
Issue number5
DOIs
StatePublished - Mar 15 1996
Externally publishedYes

Fingerprint

Induced Hyperthermia
hyperthermia
Sarcoma
Canidae
Fever
cancer
Radiation
radiation
dogs
Dogs
tumors
Neoplasms
Neoplasm Metastasis
Temperature
metastasis
Radiotherapy
Dog Diseases
Therapeutics
radiation therapy

Keywords

  • Canine sarcomas
  • Local hyperthermia
  • Radiation
  • Whole-body hyperthermia

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas. / Thrall, Donald E.; Prescott, Deborah M.; Samulski, Thaddeus V.; Rosner, Gary; Denman, David L.; Legorreta, Roberto L.; Dodge, Richard K.; Page, Rodney L.; Cline, J. Mark; Lee, Jihjong; Case, Beth C.; Evans, Sydney M.; Oleson, James R.; Dewhirst, Mark W.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 34, No. 5, 15.03.1996, p. 1087-1096.

Research output: Contribution to journalArticle

Thrall, DE, Prescott, DM, Samulski, TV, Rosner, G, Denman, DL, Legorreta, RL, Dodge, RK, Page, RL, Cline, JM, Lee, J, Case, BC, Evans, SM, Oleson, JR & Dewhirst, MW 1996, 'Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas', International Journal of Radiation Oncology, Biology, Physics, vol. 34, no. 5, pp. 1087-1096. https://doi.org/10.1016/0360-3016(95)02260-0
Thrall, Donald E. ; Prescott, Deborah M. ; Samulski, Thaddeus V. ; Rosner, Gary ; Denman, David L. ; Legorreta, Roberto L. ; Dodge, Richard K. ; Page, Rodney L. ; Cline, J. Mark ; Lee, Jihjong ; Case, Beth C. ; Evans, Sydney M. ; Oleson, James R. ; Dewhirst, Mark W. / Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas. In: International Journal of Radiation Oncology, Biology, Physics. 1996 ; Vol. 34, No. 5. pp. 1087-1096.
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abstract = "Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p <0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95{\%} confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.",
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AU - Thrall, Donald E.

AU - Prescott, Deborah M.

AU - Samulski, Thaddeus V.

AU - Rosner, Gary

AU - Denman, David L.

AU - Legorreta, Roberto L.

AU - Dodge, Richard K.

AU - Page, Rodney L.

AU - Cline, J. Mark

AU - Lee, Jihjong

AU - Case, Beth C.

AU - Evans, Sydney M.

AU - Oleson, James R.

AU - Dewhirst, Mark W.

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N2 - Purpose: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Methods and Materials: Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH + WBH. Dogs were accessioned for treatment at two institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; one during the first and one during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Results: Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH + WBH, respectively (p <0.001). There was no difference in duration of local tumor control between hyperthermia groups (p = 0.59). The time to metastasis was shorter for dogs receiving LH + WBH (p = 0.02); the hazard ratio for metastatic disease for dogs in the LH + WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH + WBH. Conclusion: The combination of LH + WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH + WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. We identified no rationale for further study of LH + WBH in combination with radiation for treatment of solid tumors.

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